Primary B-cell CNS lymphoma clinicopathologic and treatment outcomes in 89 patients from a single tertiary care center

Samir Dalia, Peter Forsyth, Julio Chavez, Samantha Price, Bijal Shah, Celeste Bello, Lubomir Sokol, Edward Pan, Eduardo Sotomayor, Ji Hyun Lee, Kate Fisher, Michael Jaglal

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Primary central nervous system lymphoma (PCNSL) is a rare aggressive variant of diffuse large B-cell lymphoma with a poor prognosis and no defined optimal therapeutic strategies. Our aim was to compare the role of intrathecal chemotherapy with current high-dose methotrexate (HDMTX) treatments. Clinicopathologic characteristics, therapy, and outcomes of patients with PCNSL at Moffitt Cancer Center were reviewed in 89 patients identified over an 11-year period. Patients treated initially with HDMTX-based therapy showed improved overall and progression-free survival, with no improvement shown with added radiation or intrathecal therapy. Age and performance status were also important prognostic indicators. Our conclusion is that initial therapy in PCNSL should include an HDMTX backbone. The use of intrathecal chemotherapy or radiation therapy initially likely does not improve outcomes. Future multicenter phase III clinical trials are needed to better establish the superior initial treatment in PCNSL.

Original languageEnglish (US)
Pages (from-to)450-456
Number of pages7
JournalInternational Journal of Hematology
Volume99
Issue number4
DOIs
StatePublished - Apr 2014

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Keywords

  • Intrathecal therapy
  • Methotrexate
  • Non-Hodgkin lymphoma
  • Primary CNS lymphoma
  • Prognostic factors
  • Rituximab

ASJC Scopus subject areas

  • Hematology

Cite this

Dalia, S., Forsyth, P., Chavez, J., Price, S., Shah, B., Bello, C., Sokol, L., Pan, E., Sotomayor, E., Lee, J. H., Fisher, K., & Jaglal, M. (2014). Primary B-cell CNS lymphoma clinicopathologic and treatment outcomes in 89 patients from a single tertiary care center. International Journal of Hematology, 99(4), 450-456. https://doi.org/10.1007/s12185-014-1540-z