Primary body cavity-based AIDS-related lymphomas

M. Qasim Ansari, D. Brian Dawson, Roland Nador, Cynthia Rutherford, Nancy R. Schneider, M. Jane Latimer, Louis Picker, Daniel M. Knowles, Robert W. McKenna

Research output: Contribution to journalArticle

221 Citations (Scopus)

Abstract

Five patients with advanced AIDS developed a unique type of high grade primary body cavity-based non-Hodgkin's lymphoma (NHL). The lymphomas were exclusively in serous effusions with no detectable mass disease in the body cavities and no lymphadenopathy or organo-megaly. All of the lymphomas exhibited virtually identical morphology, which could not be precisely classified, but appeared to bridge features of large cell immunoblastic and anaplastic large cell lymphomas. Immunophenotypically the lymphoma cells lacked expression of any B- or T-lymphocyte antigens, but expressed CD45 and the activation antigens CD30, CD38, CD71, and HLA-DR. Clonally rearranged immunoglobulin heavy chain and kappa light chain genes were identified by Southern blot analysis. Molecular studies also revealed Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) genomes and germline configuration of the c-myc protooncogene. In two cases studied cytogenetically, the lymphoma cells manifested complex chromosome abnormalities. These lymphomas are clinically and biologically unique and found predominantly in patients with advanced AIDS, in many cases with pre- existing Kaposi's sarcoma.

Original languageEnglish (US)
Pages (from-to)221-229
Number of pages9
JournalAmerican Journal of Clinical Pathology
Volume105
Issue number2
StatePublished - Feb 1996

Fingerprint

AIDS-Related Lymphoma
Lymphoma
Acquired Immunodeficiency Syndrome
CD45 Antigens
Anaplastic Large-Cell Lymphoma
Human Herpesvirus 8
Immunoglobulin Heavy Chains
Kaposi's Sarcoma
Viral Tumor Antigens
HLA-DR Antigens
Southern Blotting
Human Herpesvirus 4
Chromosome Aberrations
Non-Hodgkin's Lymphoma
Genome
T-Lymphocytes
Light
Genes

Keywords

  • AIDS-related lymphoma
  • Body cavity-based lymphoma
  • EBV-associated lymphoma
  • Kaposi's sarcoma-associated herpesvirus

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Ansari, M. Q., Dawson, D. B., Nador, R., Rutherford, C., Schneider, N. R., Latimer, M. J., ... McKenna, R. W. (1996). Primary body cavity-based AIDS-related lymphomas. American Journal of Clinical Pathology, 105(2), 221-229.

Primary body cavity-based AIDS-related lymphomas. / Ansari, M. Qasim; Dawson, D. Brian; Nador, Roland; Rutherford, Cynthia; Schneider, Nancy R.; Latimer, M. Jane; Picker, Louis; Knowles, Daniel M.; McKenna, Robert W.

In: American Journal of Clinical Pathology, Vol. 105, No. 2, 02.1996, p. 221-229.

Research output: Contribution to journalArticle

Ansari, MQ, Dawson, DB, Nador, R, Rutherford, C, Schneider, NR, Latimer, MJ, Picker, L, Knowles, DM & McKenna, RW 1996, 'Primary body cavity-based AIDS-related lymphomas', American Journal of Clinical Pathology, vol. 105, no. 2, pp. 221-229.
Ansari MQ, Dawson DB, Nador R, Rutherford C, Schneider NR, Latimer MJ et al. Primary body cavity-based AIDS-related lymphomas. American Journal of Clinical Pathology. 1996 Feb;105(2):221-229.
Ansari, M. Qasim ; Dawson, D. Brian ; Nador, Roland ; Rutherford, Cynthia ; Schneider, Nancy R. ; Latimer, M. Jane ; Picker, Louis ; Knowles, Daniel M. ; McKenna, Robert W. / Primary body cavity-based AIDS-related lymphomas. In: American Journal of Clinical Pathology. 1996 ; Vol. 105, No. 2. pp. 221-229.
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