TY - JOUR
T1 - Primary breast tumor characteristics predicting aggressive nodal involvement
AU - Ma, Aye Moe Thu
AU - Bowling, Monet
AU - Leitch, Marilyn
AU - Rao, Roshni
AU - Euhus, David M.
PY - 2007/10
Y1 - 2007/10
N2 - Background: pN3 breast cancer is historically associated with a poor prognosis, but the biology of aggressive nodal involvement or lymphatotropism is not well understood. Methods: This retrospective study compares clinical and pathological features for 1347 breast cancer patients with pN0 disease, 560 with pN1 disease, and 100 with ≥10 positive nodes (pN3 [10] disease). Results: Compared with pN1 disease, pN3 (10) disease was more frequently associated with T3-4 primaries (9% versus 38%, P ≤ .001), lobular histology (11% versus 22%, P = .01), and inflammatory cancer (1% versus 5%, P = 0.01). pN3 (10) disease was not associated with early-onset or estrogen receptor-negative breast cancer. The 5- and 10-year overall survival for pN3 (10) patients was 64% and 21%, respectively. Conclusions: The data indicates that the prognosis for pN3 (10) patients may be improving with current treatment. Molecular pathways governing aggressive lymphatotropism appear to be independent of those associated with early-onset, estrogen receptor-negative breast cancer.
AB - Background: pN3 breast cancer is historically associated with a poor prognosis, but the biology of aggressive nodal involvement or lymphatotropism is not well understood. Methods: This retrospective study compares clinical and pathological features for 1347 breast cancer patients with pN0 disease, 560 with pN1 disease, and 100 with ≥10 positive nodes (pN3 [10] disease). Results: Compared with pN1 disease, pN3 (10) disease was more frequently associated with T3-4 primaries (9% versus 38%, P ≤ .001), lobular histology (11% versus 22%, P = .01), and inflammatory cancer (1% versus 5%, P = 0.01). pN3 (10) disease was not associated with early-onset or estrogen receptor-negative breast cancer. The 5- and 10-year overall survival for pN3 (10) patients was 64% and 21%, respectively. Conclusions: The data indicates that the prognosis for pN3 (10) patients may be improving with current treatment. Molecular pathways governing aggressive lymphatotropism appear to be independent of those associated with early-onset, estrogen receptor-negative breast cancer.
KW - 10 axillary lymph nodes
KW - Breast neoplasms/mortality
KW - Breast neoplasms/pathology
KW - Carcinoma/mortality
KW - Lymphatic metastasis
KW - Prognosis
KW - Survival rate
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UR - http://www.scopus.com/inward/citedby.url?scp=34548448411&partnerID=8YFLogxK
U2 - 10.1016/j.amjsurg.2007.06.009
DO - 10.1016/j.amjsurg.2007.06.009
M3 - Article
C2 - 17826058
AN - SCOPUS:34548448411
SN - 0002-9610
VL - 194
SP - 474
EP - 476
JO - American journal of surgery
JF - American journal of surgery
IS - 4
ER -