Primary cilium and sonic hedgehog signaling during neural tube patterning: Role of GPCRs and second messengers

Kasturi Pal, Saikat Mukhopadhyay

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The ventral neural tube in vertebrates is patterned by a gradient of sonic hedgehog (Shh) secreted from the notochord and floor plate. Forward genetic screens first pointed to the role of the primary cilium in ventral neural tube patterning. Further research has shown that most components of the Shh pathway localize to or shuttle through the primary cilium. In the absence of Shh, the bifunctional Gli transcription factors are proteolytically processed into repressor forms in a protein kinase A (PKA)- and cilium-dependent manner. Recent work suggests that the orphan G-protein-coupled receptor (GPCR) Gpr161 localizes to cilia, and functions as a negative regulator of Shh signaling by determining Gli processing via cAMP signaling. The primary cilium also functions as a signaling compartment for calcium in the Shh pathway. A better understanding of the role of the cilium as a signaling compartment, and the interplay of second messenger systems that regulate PKA activation and Gli amplification during signaling is critical for deciphering the role of Shh during development, neuronal differentiation, and tumorigenesis.

Original languageEnglish (US)
Pages (from-to)337-348
Number of pages12
JournalDevelopmental Neurobiology
Volume75
Issue number4
DOIs
StatePublished - Apr 1 2015

Fingerprint

Neural Tube
Hedgehogs
Cilia
Second Messenger Systems
Cyclic AMP-Dependent Protein Kinases
Notochord
Calcium Signaling
G-Protein-Coupled Receptors
Vertebrates
Carcinogenesis
Transcription Factors
Research

Keywords

  • G-protein-coupled receptor
  • Hedgehog
  • Neural tube
  • Primary cilium
  • Protein kinase A

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

Cite this

Primary cilium and sonic hedgehog signaling during neural tube patterning : Role of GPCRs and second messengers. / Pal, Kasturi; Mukhopadhyay, Saikat.

In: Developmental Neurobiology, Vol. 75, No. 4, 01.04.2015, p. 337-348.

Research output: Contribution to journalArticle

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