Primary diffuse leptomeningeal oligodendrogliomatosis with an isolated 1p deletion

Samuel Gatzert, Aditya Durgam, Karthikram Raghuram, Amit Agarwal

Research output: Contribution to journalArticle

Abstract

We report a case of primary diffuse leptomeningeal oligodendrogliomatosis with an isolated 1p deletion confirmed by fluorescent in situ hybridization (FISH) analysis in 52 year-old man. The MRI scan in a patient presenting with progressive headache, nausea and diplopia revealed diffuse leptomeningeal thickening and enhancement without definitive evidence of an intraparenchymal lesion. Biopsy of thickened, enhancing meninges within the left sylvian fissure revealed subarachnoid proliferation of oligodendroglial cells with varying degrees of de-differentiation and sparing of the underlying cortex. An isolated 1p deletion was confirmed by FISH analysis. This is the first reported adult case of a 1p deletion in primary diffuse leptomeningeal oligodendrogliomatosis.

Original languageEnglish (US)
JournalBritish Journal of Neurosurgery
DOIs
StateAccepted/In press - Jan 1 2019
Externally publishedYes

Keywords

  • Leptomeningeal
  • MRI
  • oligodendrogliomatosis

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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