Primary hyperparathyroidism and ALS is there a relation?

Carlayne E. Jackson, A. A. Amato, W. W. Bryan, G. I. Wolfe, K. Sakhaee, R. J. Barohn

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: An association between primary hyperparathyroidism (PHP) and amyotrophic lateral sclerosis (ALS) has been noted; however, a causal relation between these disorders has not been confirmed. Patients/Methods: We report five patients (three men, two women) meeting El Escorial criteria for ALS who also had PHP. In three patients, the diagnosis of PHP was made during the laboratory evaluation for motor neuron disease, and in one patient, the diagnosis of PHP preceded the onset of weakness by 5 months and in another by 2 years. Serum calcium levels in all five patients were elevated, ranging from 11.2 to 12.8 mg/dL (normal, <10.4 mg/dL), as were levels of parathyroid hormone (PTH). Results: All five patients underwent parathyroid adenoma resection with subsequent normalization of serum calcium and PTH levels. Each patient had progressive weakness resulting in death I to 3 years following parathyroidectomy. Conclusion: Resection of parathyroid adenomas in patients meeting El Escorial criteria for ALS did not alter the course of ALS. PHP and ALS appear to be coexisting but unrelated disorders.

Original languageEnglish (US)
Pages (from-to)1795-1799
Number of pages5
JournalNeurology
Volume50
Issue number6
StatePublished - Jun 1998

Fingerprint

Motor Neuron Disease
Primary Hyperparathyroidism
Amyotrophic Lateral Sclerosis
Parathyroid Neoplasms
Parathyroid Hormone
Calcium
Parathyroidectomy
Serum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Jackson, C. E., Amato, A. A., Bryan, W. W., Wolfe, G. I., Sakhaee, K., & Barohn, R. J. (1998). Primary hyperparathyroidism and ALS is there a relation? Neurology, 50(6), 1795-1799.

Primary hyperparathyroidism and ALS is there a relation? / Jackson, Carlayne E.; Amato, A. A.; Bryan, W. W.; Wolfe, G. I.; Sakhaee, K.; Barohn, R. J.

In: Neurology, Vol. 50, No. 6, 06.1998, p. 1795-1799.

Research output: Contribution to journalArticle

Jackson, CE, Amato, AA, Bryan, WW, Wolfe, GI, Sakhaee, K & Barohn, RJ 1998, 'Primary hyperparathyroidism and ALS is there a relation?', Neurology, vol. 50, no. 6, pp. 1795-1799.
Jackson CE, Amato AA, Bryan WW, Wolfe GI, Sakhaee K, Barohn RJ. Primary hyperparathyroidism and ALS is there a relation? Neurology. 1998 Jun;50(6):1795-1799.
Jackson, Carlayne E. ; Amato, A. A. ; Bryan, W. W. ; Wolfe, G. I. ; Sakhaee, K. ; Barohn, R. J. / Primary hyperparathyroidism and ALS is there a relation?. In: Neurology. 1998 ; Vol. 50, No. 6. pp. 1795-1799.
@article{14f5baf01e0b42dfbb8cbd5e9f77ce2d,
title = "Primary hyperparathyroidism and ALS is there a relation?",
abstract = "Background: An association between primary hyperparathyroidism (PHP) and amyotrophic lateral sclerosis (ALS) has been noted; however, a causal relation between these disorders has not been confirmed. Patients/Methods: We report five patients (three men, two women) meeting El Escorial criteria for ALS who also had PHP. In three patients, the diagnosis of PHP was made during the laboratory evaluation for motor neuron disease, and in one patient, the diagnosis of PHP preceded the onset of weakness by 5 months and in another by 2 years. Serum calcium levels in all five patients were elevated, ranging from 11.2 to 12.8 mg/dL (normal, <10.4 mg/dL), as were levels of parathyroid hormone (PTH). Results: All five patients underwent parathyroid adenoma resection with subsequent normalization of serum calcium and PTH levels. Each patient had progressive weakness resulting in death I to 3 years following parathyroidectomy. Conclusion: Resection of parathyroid adenomas in patients meeting El Escorial criteria for ALS did not alter the course of ALS. PHP and ALS appear to be coexisting but unrelated disorders.",
author = "Jackson, {Carlayne E.} and Amato, {A. A.} and Bryan, {W. W.} and Wolfe, {G. I.} and K. Sakhaee and Barohn, {R. J.}",
year = "1998",
month = "6",
language = "English (US)",
volume = "50",
pages = "1795--1799",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Primary hyperparathyroidism and ALS is there a relation?

AU - Jackson, Carlayne E.

AU - Amato, A. A.

AU - Bryan, W. W.

AU - Wolfe, G. I.

AU - Sakhaee, K.

AU - Barohn, R. J.

PY - 1998/6

Y1 - 1998/6

N2 - Background: An association between primary hyperparathyroidism (PHP) and amyotrophic lateral sclerosis (ALS) has been noted; however, a causal relation between these disorders has not been confirmed. Patients/Methods: We report five patients (three men, two women) meeting El Escorial criteria for ALS who also had PHP. In three patients, the diagnosis of PHP was made during the laboratory evaluation for motor neuron disease, and in one patient, the diagnosis of PHP preceded the onset of weakness by 5 months and in another by 2 years. Serum calcium levels in all five patients were elevated, ranging from 11.2 to 12.8 mg/dL (normal, <10.4 mg/dL), as were levels of parathyroid hormone (PTH). Results: All five patients underwent parathyroid adenoma resection with subsequent normalization of serum calcium and PTH levels. Each patient had progressive weakness resulting in death I to 3 years following parathyroidectomy. Conclusion: Resection of parathyroid adenomas in patients meeting El Escorial criteria for ALS did not alter the course of ALS. PHP and ALS appear to be coexisting but unrelated disorders.

AB - Background: An association between primary hyperparathyroidism (PHP) and amyotrophic lateral sclerosis (ALS) has been noted; however, a causal relation between these disorders has not been confirmed. Patients/Methods: We report five patients (three men, two women) meeting El Escorial criteria for ALS who also had PHP. In three patients, the diagnosis of PHP was made during the laboratory evaluation for motor neuron disease, and in one patient, the diagnosis of PHP preceded the onset of weakness by 5 months and in another by 2 years. Serum calcium levels in all five patients were elevated, ranging from 11.2 to 12.8 mg/dL (normal, <10.4 mg/dL), as were levels of parathyroid hormone (PTH). Results: All five patients underwent parathyroid adenoma resection with subsequent normalization of serum calcium and PTH levels. Each patient had progressive weakness resulting in death I to 3 years following parathyroidectomy. Conclusion: Resection of parathyroid adenomas in patients meeting El Escorial criteria for ALS did not alter the course of ALS. PHP and ALS appear to be coexisting but unrelated disorders.

UR - http://www.scopus.com/inward/record.url?scp=0031776448&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031776448&partnerID=8YFLogxK

M3 - Article

VL - 50

SP - 1795

EP - 1799

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 6

ER -