Primary immune response of guinea pig spleen cells in vitro

J. Kettman, S. Ben-Sasson, J. U. Rudin

Research output: Contribution to journalArticle

3 Scopus citations


Spleen cells of the primed guinea pig, when cultured alone, failed to make a primary immune response against heterologous erythrocytes. When supplemented with lymphocytes obtained from mineral oil induced peritoneal exudate (PEL), a primary immune response against sheep, horse and chicken RBC was obtained. The kinetics, dose response and requirement of PELs for this response are reported.

Original languageEnglish (US)
Pages (from-to)131-141
Number of pages11
JournalJournal of Immunological Methods
Issue numberC
StatePublished - Apr 1978


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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