Primary intramedullary spinal cord lymphoma: A population-based study

Wuyang Yang, Tomas Garzon-Muvdi, Maria Braileanu, Jose L. Porras, Justin M. Caplan, Xiaoming Rong, Judy Huang, George I. Jallo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Primary intramedullary spinal cord lymphoma (PISCL) is a rare diagnosis with poorly understood disease progression. Clarification of the factors associated with survival in PISCL patients is warranted. Methods: We conducted a population-based cohort study utilizing prospectively collected data from the Surveillance, Epidemiology, and End Results (SEER) database. Patients with histological diagnosis of primary lymphoma in spinal cord (C72.0) from 1973 to 2012 in the SEER database were included. Multivariable survival analysis between patient, lesion characteristics, and PISCL-related death was performed to adjust for confounding factors. Results: We included 346 PISCL patients in our study. Average age was 56.5 ± 17.8 years, with 62.7% being male. Racial distribution of these patients was white (87.6%), black (8.0%), and other (4.3%). More than half (55.8%) of patients were married. The most prevalent histology of PISCL was diffuse B-cell (46.2%), and the majority (55.2%) were low stage (Ann Arbor stage I/II). Most patients (67.9%) received radiation therapy. Average survival interval of patients with PISCL-related death (n=135, 39.0%) was 27.8 months. General cumulative survival probability at 1 year, 2 years, and 5 years was 73.8%, 67.9%, and 63.1%, respectively. Multivariable accelerated failure time (AFT) regression showed follicular lymphoma (HR:0.25, P=.008) and more recent diagnosis (HR:0.96, P<.001) was positively associated with PISCL-related survival. Conversely, nonwhite race (HR:1.69, P=.046), older age (HR:1.02, P<.001), unmarried status (HR:2.14, P<.001), and higher stage (HR:1.54, P=.022) were negatively associated with survival. Conclusions: Age, race, marital status, tumor histology, tumor stage, and year of diagnosis were associated with survival of PISCL. While most PISCL-related deaths occur within a 1-year period, subsequent slow progression was observed after the first year of survival.

Original languageEnglish (US)
Pages (from-to)414-421
Number of pages8
JournalNeuro-oncology
Volume19
Issue number3
DOIs
StatePublished - Mar 1 2017
Externally publishedYes

Fingerprint

Lymphoma
Spinal Cord
Population
Survival
Histology
Epidemiology
Databases
Follicular Lymphoma
Marital Status
Survival Analysis
Non-Hodgkin's Lymphoma
Disease Progression
Neoplasms
B-Lymphocytes
Cohort Studies
Radiotherapy

Keywords

  • Intramedullary
  • Lymphoma
  • Spinal cord

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

Cite this

Yang, W., Garzon-Muvdi, T., Braileanu, M., Porras, J. L., Caplan, J. M., Rong, X., ... Jallo, G. I. (2017). Primary intramedullary spinal cord lymphoma: A population-based study. Neuro-oncology, 19(3), 414-421. https://doi.org/10.1093/neuonc/now178

Primary intramedullary spinal cord lymphoma : A population-based study. / Yang, Wuyang; Garzon-Muvdi, Tomas; Braileanu, Maria; Porras, Jose L.; Caplan, Justin M.; Rong, Xiaoming; Huang, Judy; Jallo, George I.

In: Neuro-oncology, Vol. 19, No. 3, 01.03.2017, p. 414-421.

Research output: Contribution to journalArticle

Yang, W, Garzon-Muvdi, T, Braileanu, M, Porras, JL, Caplan, JM, Rong, X, Huang, J & Jallo, GI 2017, 'Primary intramedullary spinal cord lymphoma: A population-based study', Neuro-oncology, vol. 19, no. 3, pp. 414-421. https://doi.org/10.1093/neuonc/now178
Yang, Wuyang ; Garzon-Muvdi, Tomas ; Braileanu, Maria ; Porras, Jose L. ; Caplan, Justin M. ; Rong, Xiaoming ; Huang, Judy ; Jallo, George I. / Primary intramedullary spinal cord lymphoma : A population-based study. In: Neuro-oncology. 2017 ; Vol. 19, No. 3. pp. 414-421.
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abstract = "Background: Primary intramedullary spinal cord lymphoma (PISCL) is a rare diagnosis with poorly understood disease progression. Clarification of the factors associated with survival in PISCL patients is warranted. Methods: We conducted a population-based cohort study utilizing prospectively collected data from the Surveillance, Epidemiology, and End Results (SEER) database. Patients with histological diagnosis of primary lymphoma in spinal cord (C72.0) from 1973 to 2012 in the SEER database were included. Multivariable survival analysis between patient, lesion characteristics, and PISCL-related death was performed to adjust for confounding factors. Results: We included 346 PISCL patients in our study. Average age was 56.5 ± 17.8 years, with 62.7{\%} being male. Racial distribution of these patients was white (87.6{\%}), black (8.0{\%}), and other (4.3{\%}). More than half (55.8{\%}) of patients were married. The most prevalent histology of PISCL was diffuse B-cell (46.2{\%}), and the majority (55.2{\%}) were low stage (Ann Arbor stage I/II). Most patients (67.9{\%}) received radiation therapy. Average survival interval of patients with PISCL-related death (n=135, 39.0{\%}) was 27.8 months. General cumulative survival probability at 1 year, 2 years, and 5 years was 73.8{\%}, 67.9{\%}, and 63.1{\%}, respectively. Multivariable accelerated failure time (AFT) regression showed follicular lymphoma (HR:0.25, P=.008) and more recent diagnosis (HR:0.96, P<.001) was positively associated with PISCL-related survival. Conversely, nonwhite race (HR:1.69, P=.046), older age (HR:1.02, P<.001), unmarried status (HR:2.14, P<.001), and higher stage (HR:1.54, P=.022) were negatively associated with survival. Conclusions: Age, race, marital status, tumor histology, tumor stage, and year of diagnosis were associated with survival of PISCL. While most PISCL-related deaths occur within a 1-year period, subsequent slow progression was observed after the first year of survival.",
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AU - Yang, Wuyang

AU - Garzon-Muvdi, Tomas

AU - Braileanu, Maria

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AU - Caplan, Justin M.

AU - Rong, Xiaoming

AU - Huang, Judy

AU - Jallo, George I.

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N2 - Background: Primary intramedullary spinal cord lymphoma (PISCL) is a rare diagnosis with poorly understood disease progression. Clarification of the factors associated with survival in PISCL patients is warranted. Methods: We conducted a population-based cohort study utilizing prospectively collected data from the Surveillance, Epidemiology, and End Results (SEER) database. Patients with histological diagnosis of primary lymphoma in spinal cord (C72.0) from 1973 to 2012 in the SEER database were included. Multivariable survival analysis between patient, lesion characteristics, and PISCL-related death was performed to adjust for confounding factors. Results: We included 346 PISCL patients in our study. Average age was 56.5 ± 17.8 years, with 62.7% being male. Racial distribution of these patients was white (87.6%), black (8.0%), and other (4.3%). More than half (55.8%) of patients were married. The most prevalent histology of PISCL was diffuse B-cell (46.2%), and the majority (55.2%) were low stage (Ann Arbor stage I/II). Most patients (67.9%) received radiation therapy. Average survival interval of patients with PISCL-related death (n=135, 39.0%) was 27.8 months. General cumulative survival probability at 1 year, 2 years, and 5 years was 73.8%, 67.9%, and 63.1%, respectively. Multivariable accelerated failure time (AFT) regression showed follicular lymphoma (HR:0.25, P=.008) and more recent diagnosis (HR:0.96, P<.001) was positively associated with PISCL-related survival. Conversely, nonwhite race (HR:1.69, P=.046), older age (HR:1.02, P<.001), unmarried status (HR:2.14, P<.001), and higher stage (HR:1.54, P=.022) were negatively associated with survival. Conclusions: Age, race, marital status, tumor histology, tumor stage, and year of diagnosis were associated with survival of PISCL. While most PISCL-related deaths occur within a 1-year period, subsequent slow progression was observed after the first year of survival.

AB - Background: Primary intramedullary spinal cord lymphoma (PISCL) is a rare diagnosis with poorly understood disease progression. Clarification of the factors associated with survival in PISCL patients is warranted. Methods: We conducted a population-based cohort study utilizing prospectively collected data from the Surveillance, Epidemiology, and End Results (SEER) database. Patients with histological diagnosis of primary lymphoma in spinal cord (C72.0) from 1973 to 2012 in the SEER database were included. Multivariable survival analysis between patient, lesion characteristics, and PISCL-related death was performed to adjust for confounding factors. Results: We included 346 PISCL patients in our study. Average age was 56.5 ± 17.8 years, with 62.7% being male. Racial distribution of these patients was white (87.6%), black (8.0%), and other (4.3%). More than half (55.8%) of patients were married. The most prevalent histology of PISCL was diffuse B-cell (46.2%), and the majority (55.2%) were low stage (Ann Arbor stage I/II). Most patients (67.9%) received radiation therapy. Average survival interval of patients with PISCL-related death (n=135, 39.0%) was 27.8 months. General cumulative survival probability at 1 year, 2 years, and 5 years was 73.8%, 67.9%, and 63.1%, respectively. Multivariable accelerated failure time (AFT) regression showed follicular lymphoma (HR:0.25, P=.008) and more recent diagnosis (HR:0.96, P<.001) was positively associated with PISCL-related survival. Conversely, nonwhite race (HR:1.69, P=.046), older age (HR:1.02, P<.001), unmarried status (HR:2.14, P<.001), and higher stage (HR:1.54, P=.022) were negatively associated with survival. Conclusions: Age, race, marital status, tumor histology, tumor stage, and year of diagnosis were associated with survival of PISCL. While most PISCL-related deaths occur within a 1-year period, subsequent slow progression was observed after the first year of survival.

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