TY - JOUR
T1 - Primary leiomyosarcoma of the kidney
T2 - A clinicopathologic study of 27 cases
AU - Miller, Jeremy S.
AU - Zhou, Ming
AU - Brimo, Fadi
AU - Guo, Charles C.
AU - Epstein, Jonathan I.
PY - 2010/2/1
Y1 - 2010/2/1
N2 - Primary leiomyosarcoma of the kidney is a rare entity that has not been well characterized. We retrieved 27 cases of primary renal leiomyosarcomas diagnosed at 3 institutions between 1986 and 2009. Mean patient age at diagnosis was 58.5 years (range 22 to 85), and 59% were female. Mean tumor size was 13.4 cm (range 4 to 26), and 59% of the tumors were identified in the right kidney. Detailed histologic examination was possible for 24 of the cases. Average mitotic count per 10 high-power fields was 11.1 (range 0 to 50), and the average extent of necrosis was 21% (range 0 to 60). Cellular pleomorphism was classified as either focal (n=13) or extensive (n=11) and graded as mild (n=3), moderate (n=7) or severe (n=14). Tumors were either grade 2 (n=12) or grade 3 (n=12) using the French Federation of Cancer Centers System. Direct extension beyond the kidney capsule was identified in 55% of the cases, and lymphovascular invasion was identified in 26%. Clinical follow-up information was available for 20 of the cases, and patients were followed for an average of 2.8 years (range 0.25 to 9). Distant metastases were identified in 90% of the patients, and 75% eventually died from their tumor's burden. In conclusion, primary renal leiomyosarcomas have a grim prognosis regardless of the underlying histology.
AB - Primary leiomyosarcoma of the kidney is a rare entity that has not been well characterized. We retrieved 27 cases of primary renal leiomyosarcomas diagnosed at 3 institutions between 1986 and 2009. Mean patient age at diagnosis was 58.5 years (range 22 to 85), and 59% were female. Mean tumor size was 13.4 cm (range 4 to 26), and 59% of the tumors were identified in the right kidney. Detailed histologic examination was possible for 24 of the cases. Average mitotic count per 10 high-power fields was 11.1 (range 0 to 50), and the average extent of necrosis was 21% (range 0 to 60). Cellular pleomorphism was classified as either focal (n=13) or extensive (n=11) and graded as mild (n=3), moderate (n=7) or severe (n=14). Tumors were either grade 2 (n=12) or grade 3 (n=12) using the French Federation of Cancer Centers System. Direct extension beyond the kidney capsule was identified in 55% of the cases, and lymphovascular invasion was identified in 26%. Clinical follow-up information was available for 20 of the cases, and patients were followed for an average of 2.8 years (range 0.25 to 9). Distant metastases were identified in 90% of the patients, and 75% eventually died from their tumor's burden. In conclusion, primary renal leiomyosarcomas have a grim prognosis regardless of the underlying histology.
KW - Kidney
KW - Leiomyosarcoma
KW - Sarcoma
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U2 - 10.1097/PAS.0b013e3181cad8c9
DO - 10.1097/PAS.0b013e3181cad8c9
M3 - Article
C2 - 20090506
AN - SCOPUS:75649112623
SN - 0147-5185
VL - 34
SP - 238
EP - 242
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
IS - 2
ER -