TY - JOUR
T1 - Primary melanocytic tumors of the central nervous system
T2 - Report of two cases and review of literature
AU - Trinh, Victoria
AU - Medina-Flores, Rafael
AU - Taylor, Chirstopher L.
AU - Yonas, Howard
AU - Chohan, Muhammad O.
N1 - Publisher Copyright:
© 2014 Trinh V.
PY - 2014
Y1 - 2014
N2 - Background: Primary melanocytic tumors of the central nervous system (CNS) represent only 1% of all melanomas. We report two rare cases of primary diffuse leptomeningeal melanomatosis (PDLM; case 1) and primary melanoma of the thoraco-lumbar spine (case 2).Case Description: In case 1, multiple cerebrospinal fluid (CSF) studies and a brain biopsy were non-diagnostic, with a biopsy of the cauda equina eventually demonstrating malignant melanomatosis. Diagnosis of primary spinal cord melanoma was more straightforward in case 2 with imaging and biopsy.Conclusion: PDLM and primary intramedullary spinal melanoma are rare variants of primary CNS melanoma. This report contrasts the diagnostic challenges between the two entities and alerts the neurosurgeon into considering the diagnosis with appropriate clinical presentation.
AB - Background: Primary melanocytic tumors of the central nervous system (CNS) represent only 1% of all melanomas. We report two rare cases of primary diffuse leptomeningeal melanomatosis (PDLM; case 1) and primary melanoma of the thoraco-lumbar spine (case 2).Case Description: In case 1, multiple cerebrospinal fluid (CSF) studies and a brain biopsy were non-diagnostic, with a biopsy of the cauda equina eventually demonstrating malignant melanomatosis. Diagnosis of primary spinal cord melanoma was more straightforward in case 2 with imaging and biopsy.Conclusion: PDLM and primary intramedullary spinal melanoma are rare variants of primary CNS melanoma. This report contrasts the diagnostic challenges between the two entities and alerts the neurosurgeon into considering the diagnosis with appropriate clinical presentation.
KW - CNS melanocytic tumors
KW - Diffuse leptomeningeal melanomatosis
KW - Primary CNS melanoma
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U2 - 10.4103/2152-7806.142795
DO - 10.4103/2152-7806.142795
M3 - Article
C2 - 25371847
AN - SCOPUS:84916200013
SN - 2152-7806
VL - 5
JO - Surgical Neurology International
JF - Surgical Neurology International
IS - Supplement
M1 - 142795
ER -