Primary ovarian serous carcinomas with extensive squamous differentiation: a case report and literature review

Yao Sun, Yuezhou Chen, Xiaofei Zhang, Hao Chen, Feng Zhou

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Primary ovarian serous carcinomas (OSC) with extensive squamous differentiation is a rare, and histological diagnostic criteria and biological behavior have not been fully established. We present an extremely rare case of primary OSC of the ovary with squamous differentiation. Case presentation: A 58-year-old (gravidity 3, parity 2) female was admitted complaining of abdominal distention for 6 months. No apparent tumor in the cervix was found by a physical examination. Serum levels of cancer antigen 125 (CA125) was elevated (2723.0 IU/L). Macroscopically, a 7 cm tumor of the left uterine adnexa, a 5 cm tumor of the right adnexa, and a 3 cm tumor of the omentum were found. Histological and immunochemical tests confirmed a diagnosis of OSC with squamous differentiation. Debulking surgery with tumor resection was performed. The patient was subsequently received postoperative chemotherapy. Conclusions: In summary, OSC with extensive squamous differentiation is a rare, and the inter- and intratumor heterogeneity may be the reason for this phenomenon. Histological diagnostic criteria and biological behavior have not been fully established because of the limited data.

Original languageEnglish (US)
Article number193
JournalBMC Women's Health
Volume21
Issue number1
DOIs
StatePublished - Dec 2021

Keywords

  • Ovary
  • Serous carcinoma
  • Squamous differentiation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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