Primary peptide folding dynamics observed with ultrafast temperature jump

Omar F. Mohammed, Gouri S. Jas, Milo M. Lin, Ahmed H. Zewail

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Fastest folding: An ultrafast laser temperature jump (T-jump) induces folding and unfolding of Wh5 (see picture), the shortest possible α-helical peptide. Using time-resolved fluorescence spectroscopy, the folding time of this peptide was found to span from less than one nanosecond to a few nanoseconds, redefining the meaning of ultrafast dynamics in protein and peptide folding.

Original languageEnglish (US)
Pages (from-to)5628-5632
Number of pages5
JournalAngewandte Chemie - International Edition
Volume48
Issue number31
DOIs
StatePublished - Jul 20 2009

Fingerprint

Peptides
Ultrafast lasers
Fluorescence spectroscopy
Temperature
Proteins

Keywords

  • Helix-coil transitions
  • Peptide folding
  • Protein dynamics
  • Time-resolved spectroscopy

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Primary peptide folding dynamics observed with ultrafast temperature jump. / Mohammed, Omar F.; Jas, Gouri S.; Lin, Milo M.; Zewail, Ahmed H.

In: Angewandte Chemie - International Edition, Vol. 48, No. 31, 20.07.2009, p. 5628-5632.

Research output: Contribution to journalArticle

Mohammed, Omar F. ; Jas, Gouri S. ; Lin, Milo M. ; Zewail, Ahmed H. / Primary peptide folding dynamics observed with ultrafast temperature jump. In: Angewandte Chemie - International Edition. 2009 ; Vol. 48, No. 31. pp. 5628-5632.
@article{c04156a29b5e4feca04e6e690c512cde,
title = "Primary peptide folding dynamics observed with ultrafast temperature jump",
abstract = "Fastest folding: An ultrafast laser temperature jump (T-jump) induces folding and unfolding of Wh5 (see picture), the shortest possible α-helical peptide. Using time-resolved fluorescence spectroscopy, the folding time of this peptide was found to span from less than one nanosecond to a few nanoseconds, redefining the meaning of ultrafast dynamics in protein and peptide folding.",
keywords = "Helix-coil transitions, Peptide folding, Protein dynamics, Time-resolved spectroscopy",
author = "Mohammed, {Omar F.} and Jas, {Gouri S.} and Lin, {Milo M.} and Zewail, {Ahmed H.}",
year = "2009",
month = "7",
day = "20",
doi = "10.1002/anie.200900513",
language = "English (US)",
volume = "48",
pages = "5628--5632",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "31",

}

TY - JOUR

T1 - Primary peptide folding dynamics observed with ultrafast temperature jump

AU - Mohammed, Omar F.

AU - Jas, Gouri S.

AU - Lin, Milo M.

AU - Zewail, Ahmed H.

PY - 2009/7/20

Y1 - 2009/7/20

N2 - Fastest folding: An ultrafast laser temperature jump (T-jump) induces folding and unfolding of Wh5 (see picture), the shortest possible α-helical peptide. Using time-resolved fluorescence spectroscopy, the folding time of this peptide was found to span from less than one nanosecond to a few nanoseconds, redefining the meaning of ultrafast dynamics in protein and peptide folding.

AB - Fastest folding: An ultrafast laser temperature jump (T-jump) induces folding and unfolding of Wh5 (see picture), the shortest possible α-helical peptide. Using time-resolved fluorescence spectroscopy, the folding time of this peptide was found to span from less than one nanosecond to a few nanoseconds, redefining the meaning of ultrafast dynamics in protein and peptide folding.

KW - Helix-coil transitions

KW - Peptide folding

KW - Protein dynamics

KW - Time-resolved spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=70349918273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349918273&partnerID=8YFLogxK

U2 - 10.1002/anie.200900513

DO - 10.1002/anie.200900513

M3 - Article

C2 - 19382153

AN - SCOPUS:70349918273

VL - 48

SP - 5628

EP - 5632

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 31

ER -