Primary pulmonary lymphoma in a patient with advanced AIDS

Lokesh Shahani, Megan McKenna

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Non-Hodgkin's lymphoma (NHL) is an AIDS defining lesion and risk of NHL most likely correlates with the degree of immunosuppression from HIV. Risk of NHL is highest among patients with CD4 count <50 cells/mL. Primary pulmonary lymphoma (PPL) is an infrequent cause of AIDS-related lymphoma. The authors report a patient with advanced AIDS presenting with recurrent fever and pulmonary nodule seen on the CT scan. The patient remained febrile despite being on broad spectrum antibiotics with no clear source of infection. The patient underwent a bronchoscopy with biopsy of the pulmonary lesion which was most consistent with diffuse large B-cell lymphoma. The patient was started on dose-adjusted etoposide, vincristine, doxorubicin, cyclophosphamide and prednisone (EPOCH) and was noted to be afebrile and a repeat CT scan few weeks later showed resolution of her pulmonary nodule. This case highlights the importance of considering NHL in patients with advanced AIDS presenting with pulmonary nodule and fever.

Original languageEnglish (US)
Article number203265
JournalBMJ Case Reports
Volume2014
DOIs
StatePublished - Dec 19 2014
Externally publishedYes

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Lymphoma
Acquired Immunodeficiency Syndrome
Non-Hodgkin's Lymphoma
Lung
Fever
AIDS-Related Lymphoma
Lymphoma, Large B-Cell, Diffuse
Bronchoscopy
Vincristine
Etoposide
CD4 Lymphocyte Count
Prednisone
Doxorubicin
Cyclophosphamide
Immunosuppression
HIV
Anti-Bacterial Agents
Biopsy
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Primary pulmonary lymphoma in a patient with advanced AIDS. / Shahani, Lokesh; McKenna, Megan.

In: BMJ Case Reports, Vol. 2014, 203265, 19.12.2014.

Research output: Contribution to journalArticle

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