TY - JOUR
T1 - Primary sclerosing cholangitis
T2 - Updates in diagnosis and therapy
AU - Portincasa, Piero
AU - Vacca, Michele
AU - Moschetta, Antonio
AU - Petruzzelli, Michele
AU - Palasciano, Giuseppe
AU - van Erpecum, Karel J.
AU - van Berge-Henegouwen, Gerard P.
PY - 2005/1/7
Y1 - 2005/1/7
N2 - Primary sclerosing cholangitis (PSC) is a chronic cholestatic syndrome of unknown origin mostly found in males, and characterized by diffuse inflammation and fibrosis of both intra- and extra-hepatic bile ducts. So far, PSC is considered as an autoimmune hepatobiliary disease. In most cases the progression of PSC towards liver cirrhosis and liver failure is slow but irreversible, and liver transplantation is currently the only definitive treatment. In recent years, PSC has been an area of active research worldwide with great interest in etiology, pathogenesis, diagnosis, and therapeutic options such as hydrophilic ursodeoxycholic acid and immunosuppressive agent tacrolimus. Recent updates on clinical and therapeutic aspects of PSC are discussed in the present review.
AB - Primary sclerosing cholangitis (PSC) is a chronic cholestatic syndrome of unknown origin mostly found in males, and characterized by diffuse inflammation and fibrosis of both intra- and extra-hepatic bile ducts. So far, PSC is considered as an autoimmune hepatobiliary disease. In most cases the progression of PSC towards liver cirrhosis and liver failure is slow but irreversible, and liver transplantation is currently the only definitive treatment. In recent years, PSC has been an area of active research worldwide with great interest in etiology, pathogenesis, diagnosis, and therapeutic options such as hydrophilic ursodeoxycholic acid and immunosuppressive agent tacrolimus. Recent updates on clinical and therapeutic aspects of PSC are discussed in the present review.
KW - Diagnosis
KW - Sclerosing cholangitis
KW - Therapy
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U2 - 10.3748/wjg.v11.i1.7
DO - 10.3748/wjg.v11.i1.7
M3 - Review article
C2 - 15609388
AN - SCOPUS:11844300314
SN - 1007-9327
VL - 11
SP - 7
EP - 16
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 1
ER -