Primary sclerosing cholangitis

Updates in diagnosis and therapy

Piero Portincasa, Michele Vacca, Antonio Moschetta, Michele Petruzzelli, Giuseppe Palasciano, Karel J. van Erpecum, Gerard P. van Berge-Henegouwen

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Primary sclerosing cholangitis (PSC) is a chronic cholestatic syndrome of unknown origin mostly found in males, and characterized by diffuse inflammation and fibrosis of both intra- and extra-hepatic bile ducts. So far, PSC is considered as an autoimmune hepatobiliary disease. In most cases the progression of PSC towards liver cirrhosis and liver failure is slow but irreversible, and liver transplantation is currently the only definitive treatment. In recent years, PSC has been an area of active research worldwide with great interest in etiology, pathogenesis, diagnosis, and therapeutic options such as hydrophilic ursodeoxycholic acid and immunosuppressive agent tacrolimus. Recent updates on clinical and therapeutic aspects of PSC are discussed in the present review.

Original languageEnglish (US)
Pages (from-to)7-16
Number of pages10
JournalWorld Journal of Gastroenterology
Volume11
Issue number1
StatePublished - Jan 7 2005

Fingerprint

Sclerosing Cholangitis
Therapeutics
Common Hepatic Duct
Ursodeoxycholic Acid
Liver Failure
Tacrolimus
Immunosuppressive Agents
Bile Ducts
Liver Cirrhosis
Liver Transplantation
Autoimmune Diseases
Fibrosis
Inflammation
Liver
Research

Keywords

  • Diagnosis
  • Sclerosing cholangitis
  • Therapy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Portincasa, P., Vacca, M., Moschetta, A., Petruzzelli, M., Palasciano, G., van Erpecum, K. J., & van Berge-Henegouwen, G. P. (2005). Primary sclerosing cholangitis: Updates in diagnosis and therapy. World Journal of Gastroenterology, 11(1), 7-16.

Primary sclerosing cholangitis : Updates in diagnosis and therapy. / Portincasa, Piero; Vacca, Michele; Moschetta, Antonio; Petruzzelli, Michele; Palasciano, Giuseppe; van Erpecum, Karel J.; van Berge-Henegouwen, Gerard P.

In: World Journal of Gastroenterology, Vol. 11, No. 1, 07.01.2005, p. 7-16.

Research output: Contribution to journalArticle

Portincasa, P, Vacca, M, Moschetta, A, Petruzzelli, M, Palasciano, G, van Erpecum, KJ & van Berge-Henegouwen, GP 2005, 'Primary sclerosing cholangitis: Updates in diagnosis and therapy', World Journal of Gastroenterology, vol. 11, no. 1, pp. 7-16.
Portincasa P, Vacca M, Moschetta A, Petruzzelli M, Palasciano G, van Erpecum KJ et al. Primary sclerosing cholangitis: Updates in diagnosis and therapy. World Journal of Gastroenterology. 2005 Jan 7;11(1):7-16.
Portincasa, Piero ; Vacca, Michele ; Moschetta, Antonio ; Petruzzelli, Michele ; Palasciano, Giuseppe ; van Erpecum, Karel J. ; van Berge-Henegouwen, Gerard P. / Primary sclerosing cholangitis : Updates in diagnosis and therapy. In: World Journal of Gastroenterology. 2005 ; Vol. 11, No. 1. pp. 7-16.
@article{7b28034946ad4b18978740c02ef160db,
title = "Primary sclerosing cholangitis: Updates in diagnosis and therapy",
abstract = "Primary sclerosing cholangitis (PSC) is a chronic cholestatic syndrome of unknown origin mostly found in males, and characterized by diffuse inflammation and fibrosis of both intra- and extra-hepatic bile ducts. So far, PSC is considered as an autoimmune hepatobiliary disease. In most cases the progression of PSC towards liver cirrhosis and liver failure is slow but irreversible, and liver transplantation is currently the only definitive treatment. In recent years, PSC has been an area of active research worldwide with great interest in etiology, pathogenesis, diagnosis, and therapeutic options such as hydrophilic ursodeoxycholic acid and immunosuppressive agent tacrolimus. Recent updates on clinical and therapeutic aspects of PSC are discussed in the present review.",
keywords = "Diagnosis, Sclerosing cholangitis, Therapy",
author = "Piero Portincasa and Michele Vacca and Antonio Moschetta and Michele Petruzzelli and Giuseppe Palasciano and {van Erpecum}, {Karel J.} and {van Berge-Henegouwen}, {Gerard P.}",
year = "2005",
month = "1",
day = "7",
language = "English (US)",
volume = "11",
pages = "7--16",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "1",

}

TY - JOUR

T1 - Primary sclerosing cholangitis

T2 - Updates in diagnosis and therapy

AU - Portincasa, Piero

AU - Vacca, Michele

AU - Moschetta, Antonio

AU - Petruzzelli, Michele

AU - Palasciano, Giuseppe

AU - van Erpecum, Karel J.

AU - van Berge-Henegouwen, Gerard P.

PY - 2005/1/7

Y1 - 2005/1/7

N2 - Primary sclerosing cholangitis (PSC) is a chronic cholestatic syndrome of unknown origin mostly found in males, and characterized by diffuse inflammation and fibrosis of both intra- and extra-hepatic bile ducts. So far, PSC is considered as an autoimmune hepatobiliary disease. In most cases the progression of PSC towards liver cirrhosis and liver failure is slow but irreversible, and liver transplantation is currently the only definitive treatment. In recent years, PSC has been an area of active research worldwide with great interest in etiology, pathogenesis, diagnosis, and therapeutic options such as hydrophilic ursodeoxycholic acid and immunosuppressive agent tacrolimus. Recent updates on clinical and therapeutic aspects of PSC are discussed in the present review.

AB - Primary sclerosing cholangitis (PSC) is a chronic cholestatic syndrome of unknown origin mostly found in males, and characterized by diffuse inflammation and fibrosis of both intra- and extra-hepatic bile ducts. So far, PSC is considered as an autoimmune hepatobiliary disease. In most cases the progression of PSC towards liver cirrhosis and liver failure is slow but irreversible, and liver transplantation is currently the only definitive treatment. In recent years, PSC has been an area of active research worldwide with great interest in etiology, pathogenesis, diagnosis, and therapeutic options such as hydrophilic ursodeoxycholic acid and immunosuppressive agent tacrolimus. Recent updates on clinical and therapeutic aspects of PSC are discussed in the present review.

KW - Diagnosis

KW - Sclerosing cholangitis

KW - Therapy

UR - http://www.scopus.com/inward/record.url?scp=11844300314&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11844300314&partnerID=8YFLogxK

M3 - Article

VL - 11

SP - 7

EP - 16

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 1

ER -