Primary structural analysis of the Tla region gene products, QA-2 and TL

Mark J. Soloski, Katherine R. McIntyre, Jonathan W. Uhr, Ellen S. Vitetta

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Abstract

The Tla region on the murine 17th chromosome encodes at least three gene products (Qa-1, Qa-2 and TL) which are structurally similar to the major transplantation antigens H-2K, -D and -L. In this communication we compare the tryptic peptides of two Tla region-encoded gene products, Qa-2 and TL. The results indicate that TL and Qa-2 may be only modestly related in amino acid sequence and support the previous suggestion that distinct subfamilies of class I gene products with unique biochemical and functional properties may exist.

Original languageEnglish (US)
Pages (from-to)1193-1197
Number of pages5
JournalMolecular Immunology
Volume19
Issue number9
DOIs
StatePublished - Sep 1982

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ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

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