Primer on gadolinium chemistry

A. Dean Sherry, Peter Caravan, Robert E. Lenkinski

Research output: Contribution to journalArticlepeer-review

292 Scopus citations


Gadolinium is widely known by all practitioners of magnetic resonance imaging (MRI) but few appreciate the basic solution chemistry of this trivalent lanthanide ion. Given the recent linkage between gadolinium contrast agents and nephrogenic systemic fibrosis, some basic chemistry of this ion must be more widely understood. This short primer on gadolinium chemistry is intended to provide the reader the background principles necessary to understand the basics of chelation chemistry, water hydration numbers, and the differences between thermodynamic stability and kinetic stability or inertness. We illustrate the fundamental importance of kinetic dissociation rates in determining gadolinium toxicity in vivo by presenting new data for a novel europium DOTA-tetraamide complex that is relatively unstable thermodynamically yet extraordinarily inert kinetically and also quite nontoxic. This, plus other literature evidence, forms the basis of the fundamental axiom that it is the kinetic stability of a gadolinium complex, not its thermodynamic stability, that determines its in vivo toxicity.

Original languageEnglish (US)
Pages (from-to)1240-1248
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Issue number6
StatePublished - Dec 2009


  • Gadolinium MRI contrast agents
  • Nephrogenic systemic fibrosis
  • Thermodynamic and kinetic principles

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Primer on gadolinium chemistry'. Together they form a unique fingerprint.

Cite this