Priming of naive T cells inside tumors leads to eradication of established tumors

Ping Yu, Youjin Lee, Wenhua Liu, Robert K. Chin, Jing Wang, Yang Wang, Andrea Schietinger, Mary Philip, Hans Schreiber, Yang Xin Fu

Research output: Contribution to journalArticle

269 Scopus citations

Abstract

The tumor barrier comprised of nonantigenic stromal cells may contribute to the failure of tumor rejection. The tumor-necrosis factor superfamily member LIGHT (also known as TNFSF-14) is a ligand of stromal cell-expressed lymphotoxin-β receptor and T cell-expressed herpes viral entry mediator (HVEM). Here we show that forced expression of LIGHT in the tumor environment induces a massive infiltration of naive T lymphocytes that correlates with an upregulation of both chemokine production and expression of adhesion molecules. Activation of these infiltrating T cells, possibly through HVEM, leads to the rejection of established, highly progressive tumors at local and distal sites. Our study indicates that targeting the tumor barrier may be an effective strategy for cancer immunotherapy.

Original languageEnglish (US)
Pages (from-to)141-149
Number of pages9
JournalNature Immunology
Volume5
Issue number2
DOIs
StatePublished - Feb 1 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Yu, P., Lee, Y., Liu, W., Chin, R. K., Wang, J., Wang, Y., Schietinger, A., Philip, M., Schreiber, H., & Fu, Y. X. (2004). Priming of naive T cells inside tumors leads to eradication of established tumors. Nature Immunology, 5(2), 141-149. https://doi.org/10.1038/ni1029