Primitive pineal tumor with retinoblastomatous and retinal/ciliary epithelial differentiation: an immunohistochemical study

Jack Raisanen, Hannes Vogel, Dikran S. Horoupian

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

A one year old boy was found to have a large tumor encompassing the pineal region and extending towards the third and lateral ventricles and quadrigeminal plate. The tumor was composed mostly of small, undifferentiated cells. Some small cells were arranged in Flexner-Wintersteiner rosettes and a few displayed fleurettes. The tumor contained immature cartilage and skeletal muscle and numerous clusters of pigmented epithelial-like cells which, histologically, resembled those found in melanotic neuroectodermal tumors of infancy (retinal anlage tumors) and retinal or ciliary epithelium. Immunologic stains demonstrated neurofilaments, synaptophysin and retinal S-antigen in some of the small cells and transthyretin in some of the epithelial-like cells. The findings indicate that certain primary pineal parenchymal tumors have features in common with tumors of the ocular medullary epithelium.

Original languageEnglish (US)
Pages (from-to)165-170
Number of pages6
JournalJournal of Neuro-Oncology
Volume9
Issue number2
DOIs
StatePublished - Oct 1 1990

Keywords

  • pineoblastoma
  • primitive pineal tumor
  • retinal S-antigen
  • retinal anlage tumor
  • retinoblastoma
  • transthyretin

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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