Prinzmetal's angina during 5-fluorouracil chemotherapy

Neal S. Kleiman, Daniel E. Lehane, Charles E. Geyer, Craig M. Pratt, James B. Young

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Variant angina developed during intravenous 5-fluorouracil therapy in a patient without prior history of angina pectoris. Ambulatory electrocardiography demonstrated S-T segment elevation and ventricular ectopy during pain, whereas no symptoms or S-T segment changes occurred during placebo therapy. Prophylaxis with both nifedipine and diltiazem was successful in preventing recurrence. It is believed that 5-fluorouracil induced coronary vasospasm and that this was prevented by prophylactic calcium antagonist therapy. Drug-induced coronary artery spasm may be the cause of 5-fluorouracil-associated chest pain.

Original languageEnglish (US)
Pages (from-to)566-568
Number of pages3
JournalThe American Journal of Medicine
Volume82
Issue number3
DOIs
StatePublished - Mar 1987

ASJC Scopus subject areas

  • Medicine(all)

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    Kleiman, N. S., Lehane, D. E., Geyer, C. E., Pratt, C. M., & Young, J. B. (1987). Prinzmetal's angina during 5-fluorouracil chemotherapy. The American Journal of Medicine, 82(3), 566-568. https://doi.org/10.1016/0002-9343(87)90465-7