Prion-like polymerization as a signaling mechanism

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

The innate immune system uses pattern recognition receptors such as RIG-I and NLRP3 to sense pathogen invasion and other danger signals. Activation of these receptors induces robust signal transduction cascades that trigger the production of cytokines important for host protection. MAVS and ASC are essential adaptor proteins downstream of RIG-I and NLRP3, respectively, and both contain N-terminal domains belonging to the death domain superfamily. Recent studies suggest that both MAVS and ASC form functional prion-like fibers through their respective death domains to propagate downstream signaling. Here, we review these findings, and in this context discuss the emerging concept of prion-like polymerization in signal transduction. We further examine the potential benefits of this signaling strategy, including signal amplification, host evolutionary advantage, and molecular memory.

Original languageEnglish (US)
Pages (from-to)622-630
Number of pages9
JournalTrends in Immunology
Volume35
Issue number12
DOIs
StatePublished - Dec 1 2014

Keywords

  • Pattern recognition receptors
  • Prion-like polymerization
  • Signal transduction
  • Signaling

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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