Prion-Like Propagation of Protein Aggregation and Related Therapeutic Strategies

Sarah K. Kaufman; Marc I. Diamond

doi:10.1007/s13311-013-0196-3

Prion-Like Propagation of Protein Aggregation and Related Therapeutic Strategies

Sarah K. Kaufman, Marc I. Diamond

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

Many neurodegenerative diseases are characterized by the progressive accumulation of aggregated protein. Recent evidence suggests the prion-like propagation of protein misfolding underlies the spread of pathology observed in these diseases. This review traces our understanding of the mechanisms that underlie this phenomenon and discusses related therapeutic strategies that derive from it.

Original language	English (US)
Pages (from-to)	371-382
Number of pages	12
Journal	Neurotherapeutics
Volume	10
Issue number	3
DOIs	https://doi.org/10.1007/s13311-013-0196-3
State	Published - Jul 2013

Keywords

Networks
Neurodegeneration
Prion
Templated conformational change
Trans-cellular propagation

ASJC Scopus subject areas

Pharmacology
Clinical Neurology
Pharmacology (medical)

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10.1007/s13311-013-0196-3

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title = "Prion-Like Propagation of Protein Aggregation and Related Therapeutic Strategies",

abstract = "Many neurodegenerative diseases are characterized by the progressive accumulation of aggregated protein. Recent evidence suggests the prion-like propagation of protein misfolding underlies the spread of pathology observed in these diseases. This review traces our understanding of the mechanisms that underlie this phenomenon and discusses related therapeutic strategies that derive from it.",

keywords = "Networks, Neurodegeneration, Prion, Templated conformational change, Trans-cellular propagation",

author = "Kaufman, {Sarah K.} and Diamond, {Marc I.}",

note = "Funding Information: This work was supported by the National Institutes of Health (NINDS); the Muscular Dystrophy Association; the American Health Assistance Foundation; the Ruth K. Broad Foundation; the Tau Consortium; a pilot grant from the Hope Center for Neurological Disorders at Washington University in St. Louis. ",

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AU - Kaufman, Sarah K.

AU - Diamond, Marc I.

N1 - Funding Information: This work was supported by the National Institutes of Health (NINDS); the Muscular Dystrophy Association; the American Health Assistance Foundation; the Ruth K. Broad Foundation; the Tau Consortium; a pilot grant from the Hope Center for Neurological Disorders at Washington University in St. Louis.

PY - 2013/7

Y1 - 2013/7

N2 - Many neurodegenerative diseases are characterized by the progressive accumulation of aggregated protein. Recent evidence suggests the prion-like propagation of protein misfolding underlies the spread of pathology observed in these diseases. This review traces our understanding of the mechanisms that underlie this phenomenon and discusses related therapeutic strategies that derive from it.

AB - Many neurodegenerative diseases are characterized by the progressive accumulation of aggregated protein. Recent evidence suggests the prion-like propagation of protein misfolding underlies the spread of pathology observed in these diseases. This review traces our understanding of the mechanisms that underlie this phenomenon and discusses related therapeutic strategies that derive from it.

KW - Networks

KW - Neurodegeneration

KW - Prion

KW - Templated conformational change

KW - Trans-cellular propagation

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JO - Neurotherapeutics

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ER -

Prion-Like Propagation of Protein Aggregation and Related Therapeutic Strategies

Abstract

Keywords

ASJC Scopus subject areas

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