Prion-Like Propagation of Protein Aggregation and Related Therapeutic Strategies

Sarah K. Kaufman, Marc I. Diamond

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Many neurodegenerative diseases are characterized by the progressive accumulation of aggregated protein. Recent evidence suggests the prion-like propagation of protein misfolding underlies the spread of pathology observed in these diseases. This review traces our understanding of the mechanisms that underlie this phenomenon and discusses related therapeutic strategies that derive from it.

Original languageEnglish (US)
Pages (from-to)371-382
Number of pages12
JournalNeurotherapeutics
Volume10
Issue number3
DOIs
StatePublished - Jul 1 2013

Keywords

  • Networks
  • Neurodegeneration
  • Prion
  • Templated conformational change
  • Trans-cellular propagation

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)

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