Prized malaria drug target nailed

Pradipsinh K. Rathod, Margaret A. Phillips

Research output: Contribution to journalShort survey

14 Scopus citations

Abstract

The structure of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase, a target of clinically established antimalarial drugs, reveals the nature of inhibitor binding, drug resistance and autologous gene repression, all of which influence species-specific drug sensitivity.

Original languageEnglish (US)
Pages (from-to)316-318
Number of pages3
JournalNature Structural Biology
Volume10
Issue number5
DOIs
StatePublished - May 1 2003

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ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics

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