Prized malaria drug target nailed

Pradipsinh K. Rathod, Margaret A. Phillips

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The structure of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase, a target of clinically established antimalarial drugs, reveals the nature of inhibitor binding, drug resistance and autologous gene repression, all of which influence species-specific drug sensitivity.

Original languageEnglish (US)
Pages (from-to)316-318
Number of pages3
JournalNature Structural Biology
Volume10
Issue number5
DOIs
StatePublished - May 1 2003

Fingerprint

Antimalarials
Plasmodium falciparum
Drug Resistance
Malaria
Pharmaceutical Preparations
Genes
thymidylate synthase-dihydrofolate reductase

ASJC Scopus subject areas

  • Biochemistry
  • Structural Biology
  • Genetics

Cite this

Prized malaria drug target nailed. / Rathod, Pradipsinh K.; Phillips, Margaret A.

In: Nature Structural Biology, Vol. 10, No. 5, 01.05.2003, p. 316-318.

Research output: Contribution to journalArticle

Rathod, Pradipsinh K. ; Phillips, Margaret A. / Prized malaria drug target nailed. In: Nature Structural Biology. 2003 ; Vol. 10, No. 5. pp. 316-318.
@article{1815aa693b2a4062b78417071534c429,
title = "Prized malaria drug target nailed",
abstract = "The structure of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase, a target of clinically established antimalarial drugs, reveals the nature of inhibitor binding, drug resistance and autologous gene repression, all of which influence species-specific drug sensitivity.",
author = "Rathod, {Pradipsinh K.} and Phillips, {Margaret A.}",
year = "2003",
month = "5",
day = "1",
doi = "10.1038/nsb0503-316",
language = "English (US)",
volume = "10",
pages = "316--318",
journal = "Nature Structural and Molecular Biology",
issn = "1545-9993",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Prized malaria drug target nailed

AU - Rathod, Pradipsinh K.

AU - Phillips, Margaret A.

PY - 2003/5/1

Y1 - 2003/5/1

N2 - The structure of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase, a target of clinically established antimalarial drugs, reveals the nature of inhibitor binding, drug resistance and autologous gene repression, all of which influence species-specific drug sensitivity.

AB - The structure of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase, a target of clinically established antimalarial drugs, reveals the nature of inhibitor binding, drug resistance and autologous gene repression, all of which influence species-specific drug sensitivity.

UR - http://www.scopus.com/inward/record.url?scp=0037407201&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037407201&partnerID=8YFLogxK

U2 - 10.1038/nsb0503-316

DO - 10.1038/nsb0503-316

M3 - Article

C2 - 12714998

AN - SCOPUS:0037407201

VL - 10

SP - 316

EP - 318

JO - Nature Structural and Molecular Biology

JF - Nature Structural and Molecular Biology

SN - 1545-9993

IS - 5

ER -