Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis

John C. Scatizzi, Jack Hutcheson, Emily Bickel, G. Kenneth Haines, Harris Perlman

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Rheumatoid arthritis is an autoimmune disease characterized by hyperplasia of the synovial lining and destruction of cartilage and bone. Recent studies have suggested that a lack of apoptosis contributes to the hyperplasia of the synovial lining and to the failure in eliminating autoreactive cells. Mice lacking Fas or Bim, two pro-apoptotic proteins that mediate the extrinsic and intrinsic death cascades, respectively, develop enhanced K/BxN serum transfer-induced arthritis. Since the pro-apoptotic protein Bid functions as an intermediate between the extrinsic and intrinsic apoptotic pathways, we examined the role that it plays in inflammatory arthritis. Mice deficient in Bid (Bid-/-) show a delay in the resolution of K/BxN serum transfer-induced arthritis. Bid-/- mice display increased inflammation, bone destruction, and pannus formation compared to wild-type mice. Furthermore, Bid-/- mice have elevated levels of CXC chemokine and IL-1β in serum, which are associated with more inflammatory cells throughout the arthritic joint. In addition, there are fewer apoptotic cells in the synovium of Bid-/- compared to Wt mice. These data suggest that extrinsic and intrinsic apoptotic pathways cooperate through Bid to limit development of inflammatory arthritis.

Original languageEnglish (US)
Article numberR49
JournalArthritis Research and Therapy
Volume9
DOIs
StatePublished - May 17 2007

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Arthritis
Apoptosis Regulatory Proteins
Hyperplasia
Serum
CXC Chemokines
Osteitis
Synovial Membrane
Interleukin-1
Autoimmune Diseases
Cartilage
Rheumatoid Arthritis
Joints
Apoptosis
Bone and Bones

ASJC Scopus subject areas

  • Rheumatology
  • Medicine(all)

Cite this

Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis. / Scatizzi, John C.; Hutcheson, Jack; Bickel, Emily; Haines, G. Kenneth; Perlman, Harris.

In: Arthritis Research and Therapy, Vol. 9, R49, 17.05.2007.

Research output: Contribution to journalArticle

Scatizzi, John C. ; Hutcheson, Jack ; Bickel, Emily ; Haines, G. Kenneth ; Perlman, Harris. / Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis. In: Arthritis Research and Therapy. 2007 ; Vol. 9.
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