Probe-based confocal laser endomicroscopy for indeterminate biliary strictures: Refinement of the image interpretation classification

Michel Kahaleh, Marc Giovannini, Priya Jamidar, S. Ian Gan, Paola Cesaro, Fabrice Caillol, Bernard Filoche, Kunal Karia, Ioana Smith, Monica Gaidhane, Adam Slivka

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background. Accurate diagnosis and clinical management of indeterminate biliary strictures are often a challenge. Tissue confirmation modalities during Endoscopic Retrograde Cholangiopancreatography (ERCP) suffer from low sensitivity and poor diagnostic accuracy. Probe-based confocal laser endomicroscopy (pCLE) has been shown to be sensitive for malignant strictures characterization (98%) but lacks specificity (67%) due to inflammatory conditions inducing false positives. Methods. Six pCLE experts validated the Paris Classification, designed for diagnosing inflammatory biliary strictures, using a set of 40 pCLE sequences obtained during the prospective registry (19 inflammatory, 6 benign, and 15 malignant). The 4 criteria used included (1) multiple thin white bands, (2) dark granular pattern with scales, (3) increased space between scales, and (4) thickened reticular structures. Interobserver agreement was further calculated on a separate set of 18 pCLE sequences. Results. Overall accuracy was 82.5% (n = 40 retrospectively diagnosed) versus 81% (n = 89 prospectively collected) for the registry, resulting in a sensitivity of 81.2% (versus 98% for the prospective study) and a specificity of 83.3% (versus 67% for the prospective study). The corresponding interobserver agreement for 18 pCLE clips was fair (k = 0.37). Conclusion. Specificity of pCLE using the Paris Classification for the characterization of indeterminate bile duct stricture was increased, without impacting the overall accuracy.

Original languageEnglish (US)
Article number675210
JournalGastroenterology Research and Practice
Volume2015
DOIs
StatePublished - 2015
Externally publishedYes

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Pathologic Constriction
Lasers
Paris
Registries
Prospective Studies
Endoscopic Retrograde Cholangiopancreatography
Bile Ducts
Surgical Instruments

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Probe-based confocal laser endomicroscopy for indeterminate biliary strictures : Refinement of the image interpretation classification. / Kahaleh, Michel; Giovannini, Marc; Jamidar, Priya; Gan, S. Ian; Cesaro, Paola; Caillol, Fabrice; Filoche, Bernard; Karia, Kunal; Smith, Ioana; Gaidhane, Monica; Slivka, Adam.

In: Gastroenterology Research and Practice, Vol. 2015, 675210, 2015.

Research output: Contribution to journalArticle

Kahaleh, M, Giovannini, M, Jamidar, P, Gan, SI, Cesaro, P, Caillol, F, Filoche, B, Karia, K, Smith, I, Gaidhane, M & Slivka, A 2015, 'Probe-based confocal laser endomicroscopy for indeterminate biliary strictures: Refinement of the image interpretation classification', Gastroenterology Research and Practice, vol. 2015, 675210. https://doi.org/10.1155/2015/675210
Kahaleh, Michel ; Giovannini, Marc ; Jamidar, Priya ; Gan, S. Ian ; Cesaro, Paola ; Caillol, Fabrice ; Filoche, Bernard ; Karia, Kunal ; Smith, Ioana ; Gaidhane, Monica ; Slivka, Adam. / Probe-based confocal laser endomicroscopy for indeterminate biliary strictures : Refinement of the image interpretation classification. In: Gastroenterology Research and Practice. 2015 ; Vol. 2015.
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