In our ongoing efforts to develop new methods for lipopolysaccharide (LPS) detoxification, we have screened lipase/ esterase libraries for the ability to deacylate the 2′- and 3′-fatty acid chains from lipid A: the most active esterases were successfully employed to inactivate LPSs in a crude concentrated cell supernatant of E. Coli containing a recombinant single chain antibody (scFv).
|Original language||English (US)|
|Number of pages||2|
|Publication status||Published - Feb 21 2004|
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