Probing the mechanisms of intradialytic hypertension: A pilot study targeting endothelial cell dysfunction

Jula K. Inrig, Peter Van Buren, Catherine Kim, Wanpen Vongpatanasin, Thomas J. Povsic, Robert Toto

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Background and objectives Intradialytic hypertensionmay be caused by an impaired endothelial cell response to hemodialysis. Carvedilol has been shown to improve endothelial cell function in vivo and to block endothelin-1 release in vitro. This study hypothesized that carvedilol would improve endothelial cell function and reduce the occurrence of intradialytic hypertension. Design, setting, participants, & measurements A prospective 12-week pilot study of carvedilol titrated to 50 mg twice daily was performed among 25 hemodialysis participants with intradialytic hypertension. Each patient served as his or her own control. Paired tests were used to analyze changes in BP and endothelial cell function- assessed by flow-mediated vasodilation, endothelial progenitor cells (aldehyde dehydrogenase bright activity and CD34+CD133+), asymmetric dimethylarginine, and endothelin-1-from baseline to study end. Results Flow-mediated vasodilation was significantly improved with carvedilol (from 1.03% to 1.40%, P=0.02). There was no significant change in endothelial progenitor cells, endothelin-1, or asymmetric dimethylarginine.Although prehemodialysis systolic BPwas unchanged (144-146mmHg, P=0.5), posthemodialysis systolic BP, 44-hour ambulatory systolic BP, and the frequency of intradialytic hypertension decreased with carvedilol (159-142 mmHg, P<0.001; 155-148 mmHg, P=0.05; and 77% [4.6 of 6] to 28% [1.7 of 6], P<0.001, respectively). Conclusions Among hemodialysis participants with intradialytic hypertension, targeting endothelial cell dysfunction with carvedilol was associated with modest improvements in endothelial function, improved intradialytic and interdialytic BP, and reduced frequency of intradialytic hypertension. Randomized controlled trials are required to confirm these findings.

Original languageEnglish (US)
Pages (from-to)1300-1309
Number of pages10
JournalClinical Journal of the American Society of Nephrology
Volume7
Issue number8
DOIs
StatePublished - Aug 1 2012

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

Fingerprint Dive into the research topics of 'Probing the mechanisms of intradialytic hypertension: A pilot study targeting endothelial cell dysfunction'. Together they form a unique fingerprint.

  • Cite this