TY - JOUR
T1 - Processed vietnamese ginseng
T2 - Preliminary results in chemistry and biological activity
AU - Le, Thi Hong Van
AU - Lee, Seo Young
AU - Kim, Tae Ryong
AU - Kim, Jae Young
AU - Kwon, Sung Won
AU - Nguyen, Ngoc Khoi
AU - Park, Jeong Hill
AU - Nguyen, Minh Duc
N1 - Funding Information:
This work was supported by the grant from the Ministry of Education, Science, and Technology of Korea ( No. 2012048796 ), Rural Development Administration of Korea ( No. PJ008202022013 ), and Ministry of Science and Technology of The Socialist Republic of Vietnam ( No. KC 10.25/11-15 ).
Publisher Copyright:
© 2014, The Korean Society of Ginseng, Published by Elsevier.
PY - 2014/10/15
Y1 - 2014/10/15
N2 - Background: This study was carried out to investigate the effect of the steaming process on chemical constituents, free radical scavenging activity, and antiproliferative effect of Vietnamese ginseng. Methods: Samples of powdered Vietnamese ginseng were steamed at 120C for various times and their extracts were subjected to chemical and biological studies. Results: Upon steaming, contents of polar ginsenosides, such as Rb1, Rc, Rd, Re, and Rg1, were rapidly decreased, whereas less polar ginsenosides such as Rg3, Rg5, Rk1, Rk3, and Rh4 were increased as reported previously. However, ocotillol type saponins, which have no glycosyl moiety at the C-20 position, were relatively stable on steaming. The radical scavenging activity was increased continuously up to 20 h of steaming. Similarly, the antiproliferative activity against A549 lung cancer cells was also increased. Conclusion: It seems that the antiproliferative activity is closely related to the contents of ginsenoside Rg3, Rg5, and Rk1.
AB - Background: This study was carried out to investigate the effect of the steaming process on chemical constituents, free radical scavenging activity, and antiproliferative effect of Vietnamese ginseng. Methods: Samples of powdered Vietnamese ginseng were steamed at 120C for various times and their extracts were subjected to chemical and biological studies. Results: Upon steaming, contents of polar ginsenosides, such as Rb1, Rc, Rd, Re, and Rg1, were rapidly decreased, whereas less polar ginsenosides such as Rg3, Rg5, Rk1, Rk3, and Rh4 were increased as reported previously. However, ocotillol type saponins, which have no glycosyl moiety at the C-20 position, were relatively stable on steaming. The radical scavenging activity was increased continuously up to 20 h of steaming. Similarly, the antiproliferative activity against A549 lung cancer cells was also increased. Conclusion: It seems that the antiproliferative activity is closely related to the contents of ginsenoside Rg3, Rg5, and Rk1.
KW - Antiproliferation
KW - Ginsenoside
KW - Panax vietnamensis
KW - Steaming
KW - Vietnamese ginseng
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U2 - 10.1016/j.jgr.2013.11.015
DO - 10.1016/j.jgr.2013.11.015
M3 - Article
C2 - 24748840
AN - SCOPUS:84921928363
SN - 1226-8453
VL - 38
SP - 154
EP - 159
JO - Journal of Ginseng Research
JF - Journal of Ginseng Research
IS - 2
ER -