Processed vietnamese ginseng: Preliminary results in chemistry and biological activity

Thi Hong Van Le, Seo Young Lee, Tae Ryong Kim, Jae Young Kim, Sung Won Kwon, Ngoc Khoi Nguyen, Jeong Hill Park, Minh Duc Nguyen

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: This study was carried out to investigate the effect of the steaming process on chemical constituents, free radical scavenging activity, and antiproliferative effect of Vietnamese ginseng. Methods: Samples of powdered Vietnamese ginseng were steamed at 120C for various times and their extracts were subjected to chemical and biological studies. Results: Upon steaming, contents of polar ginsenosides, such as Rb1, Rc, Rd, Re, and Rg1, were rapidly decreased, whereas less polar ginsenosides such as Rg3, Rg5, Rk1, Rk3, and Rh4 were increased as reported previously. However, ocotillol type saponins, which have no glycosyl moiety at the C-20 position, were relatively stable on steaming. The radical scavenging activity was increased continuously up to 20 h of steaming. Similarly, the antiproliferative activity against A549 lung cancer cells was also increased. Conclusion: It seems that the antiproliferative activity is closely related to the contents of ginsenoside Rg3, Rg5, and Rk1.

Original languageEnglish (US)
Pages (from-to)154-159
Number of pages6
JournalJournal of Ginseng Research
Volume38
Issue number2
DOIs
StatePublished - Oct 15 2014

Fingerprint

Ginsenosides
Panax
steaming
Scavenging
Bioactivity
bioactive properties
chemistry
Chemical Phenomena
Saponins
Free Radicals
Lung Neoplasms
Cells
lung neoplasms
saponins
extracts
ginsenosides
sampling
ginsenoside Rg5
ginsenoside Rg3
ginsenoside Rk1

Keywords

  • Antiproliferation
  • Ginsenoside
  • Panax vietnamensis
  • Steaming
  • Vietnamese ginseng

ASJC Scopus subject areas

  • Biotechnology
  • Plant Science
  • Complementary and alternative medicine
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

Cite this

Le, T. H. V., Lee, S. Y., Kim, T. R., Kim, J. Y., Kwon, S. W., Nguyen, N. K., ... Nguyen, M. D. (2014). Processed vietnamese ginseng: Preliminary results in chemistry and biological activity. Journal of Ginseng Research, 38(2), 154-159. https://doi.org/10.1016/j.jgr.2013.11.015

Processed vietnamese ginseng : Preliminary results in chemistry and biological activity. / Le, Thi Hong Van; Lee, Seo Young; Kim, Tae Ryong; Kim, Jae Young; Kwon, Sung Won; Nguyen, Ngoc Khoi; Park, Jeong Hill; Nguyen, Minh Duc.

In: Journal of Ginseng Research, Vol. 38, No. 2, 15.10.2014, p. 154-159.

Research output: Contribution to journalArticle

Le, THV, Lee, SY, Kim, TR, Kim, JY, Kwon, SW, Nguyen, NK, Park, JH & Nguyen, MD 2014, 'Processed vietnamese ginseng: Preliminary results in chemistry and biological activity', Journal of Ginseng Research, vol. 38, no. 2, pp. 154-159. https://doi.org/10.1016/j.jgr.2013.11.015
Le, Thi Hong Van ; Lee, Seo Young ; Kim, Tae Ryong ; Kim, Jae Young ; Kwon, Sung Won ; Nguyen, Ngoc Khoi ; Park, Jeong Hill ; Nguyen, Minh Duc. / Processed vietnamese ginseng : Preliminary results in chemistry and biological activity. In: Journal of Ginseng Research. 2014 ; Vol. 38, No. 2. pp. 154-159.
@article{3fcb66365f2f428e9b5558173cbe09fb,
title = "Processed vietnamese ginseng: Preliminary results in chemistry and biological activity",
abstract = "Background: This study was carried out to investigate the effect of the steaming process on chemical constituents, free radical scavenging activity, and antiproliferative effect of Vietnamese ginseng. Methods: Samples of powdered Vietnamese ginseng were steamed at 120C for various times and their extracts were subjected to chemical and biological studies. Results: Upon steaming, contents of polar ginsenosides, such as Rb1, Rc, Rd, Re, and Rg1, were rapidly decreased, whereas less polar ginsenosides such as Rg3, Rg5, Rk1, Rk3, and Rh4 were increased as reported previously. However, ocotillol type saponins, which have no glycosyl moiety at the C-20 position, were relatively stable on steaming. The radical scavenging activity was increased continuously up to 20 h of steaming. Similarly, the antiproliferative activity against A549 lung cancer cells was also increased. Conclusion: It seems that the antiproliferative activity is closely related to the contents of ginsenoside Rg3, Rg5, and Rk1.",
keywords = "Antiproliferation, Ginsenoside, Panax vietnamensis, Steaming, Vietnamese ginseng",
author = "Le, {Thi Hong Van} and Lee, {Seo Young} and Kim, {Tae Ryong} and Kim, {Jae Young} and Kwon, {Sung Won} and Nguyen, {Ngoc Khoi} and Park, {Jeong Hill} and Nguyen, {Minh Duc}",
year = "2014",
month = "10",
day = "15",
doi = "10.1016/j.jgr.2013.11.015",
language = "English (US)",
volume = "38",
pages = "154--159",
journal = "Journal of Ginseng Research",
issn = "1226-8453",
publisher = "The Korean Society of Ginseng",
number = "2",

}

TY - JOUR

T1 - Processed vietnamese ginseng

T2 - Preliminary results in chemistry and biological activity

AU - Le, Thi Hong Van

AU - Lee, Seo Young

AU - Kim, Tae Ryong

AU - Kim, Jae Young

AU - Kwon, Sung Won

AU - Nguyen, Ngoc Khoi

AU - Park, Jeong Hill

AU - Nguyen, Minh Duc

PY - 2014/10/15

Y1 - 2014/10/15

N2 - Background: This study was carried out to investigate the effect of the steaming process on chemical constituents, free radical scavenging activity, and antiproliferative effect of Vietnamese ginseng. Methods: Samples of powdered Vietnamese ginseng were steamed at 120C for various times and their extracts were subjected to chemical and biological studies. Results: Upon steaming, contents of polar ginsenosides, such as Rb1, Rc, Rd, Re, and Rg1, were rapidly decreased, whereas less polar ginsenosides such as Rg3, Rg5, Rk1, Rk3, and Rh4 were increased as reported previously. However, ocotillol type saponins, which have no glycosyl moiety at the C-20 position, were relatively stable on steaming. The radical scavenging activity was increased continuously up to 20 h of steaming. Similarly, the antiproliferative activity against A549 lung cancer cells was also increased. Conclusion: It seems that the antiproliferative activity is closely related to the contents of ginsenoside Rg3, Rg5, and Rk1.

AB - Background: This study was carried out to investigate the effect of the steaming process on chemical constituents, free radical scavenging activity, and antiproliferative effect of Vietnamese ginseng. Methods: Samples of powdered Vietnamese ginseng were steamed at 120C for various times and their extracts were subjected to chemical and biological studies. Results: Upon steaming, contents of polar ginsenosides, such as Rb1, Rc, Rd, Re, and Rg1, were rapidly decreased, whereas less polar ginsenosides such as Rg3, Rg5, Rk1, Rk3, and Rh4 were increased as reported previously. However, ocotillol type saponins, which have no glycosyl moiety at the C-20 position, were relatively stable on steaming. The radical scavenging activity was increased continuously up to 20 h of steaming. Similarly, the antiproliferative activity against A549 lung cancer cells was also increased. Conclusion: It seems that the antiproliferative activity is closely related to the contents of ginsenoside Rg3, Rg5, and Rk1.

KW - Antiproliferation

KW - Ginsenoside

KW - Panax vietnamensis

KW - Steaming

KW - Vietnamese ginseng

UR - http://www.scopus.com/inward/record.url?scp=84921928363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921928363&partnerID=8YFLogxK

U2 - 10.1016/j.jgr.2013.11.015

DO - 10.1016/j.jgr.2013.11.015

M3 - Article

C2 - 24748840

AN - SCOPUS:84921928363

VL - 38

SP - 154

EP - 159

JO - Journal of Ginseng Research

JF - Journal of Ginseng Research

SN - 1226-8453

IS - 2

ER -