Procoagulant activity of human tumours

Existence of Xa and thrombin-like activities

R. Sarode, N. Marwaha, N. M. Gupta

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We have analysed 15 infiltrating duct carcinomas of the breast, 10 gastrointestinal adenocarcinomas, one each of the thyroid and larynx, and four mesenchymal tumours for the presence and the nature of procoagulant activity (PCA). The metastatic tumours had a significantly higher PCA (P = 0.01-0.001) as compared to the non-metastatic tumours in the respective groups, and almost 20-25 times the activity as compared to normal tissue (P = 0.001). Although the majority of the tumours had FVII-dependent tissue thromboplastin-like activity, some of the tumour homogenates revealed the presence of an FVII-independent PCA. Unlike the known alternate PCA, which acts via factor X activation, this PCA was factor X independent. In caused clost formation in FX-deficient plasma (six cases) and purified fibrinogen solution (four cases), indicating the presence of a Xa-like enzyme or a thrombin-like activity respectively.

Original languageEnglish (US)
Pages (from-to)29-31
Number of pages3
JournalBritish Journal of Cancer
Volume61
Issue number1
StatePublished - 1990

Fingerprint

Human Activities
Thrombin
cancer procoagulant
Neoplasms
Carcinoma, Ductal, Breast
Factor X
Thromboplastin
Larynx
Fibrinogen
Thyroid Gland
Adenocarcinoma
Breast
Enzymes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Procoagulant activity of human tumours : Existence of Xa and thrombin-like activities. / Sarode, R.; Marwaha, N.; Gupta, N. M.

In: British Journal of Cancer, Vol. 61, No. 1, 1990, p. 29-31.

Research output: Contribution to journalArticle

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