Production and applications of copper-64 radiopharmaceuticals

Xiankai Sun, Carolyn J. Anderson

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

The goal of this chapter is to discuss the production and applications of copper radionuclides in nuclear medicine. The interest in copper radionuclides for PET imaging and targeted radiotherapy of cancer, particularly the use of 64Cu, is increasing. Copper-64 has attractive decay properties for PET imaging and therapy, and can be used in a wide variety of applications. This chapter provides information related to the production of the radionuclides, the radiochemistry for labeling them to chelators and chelator-biomolecule conjugates, and also describes the biologic methods for evaluating compounds as radiopharmaceuticals.

Original languageEnglish (US)
Pages (from-to)237-261
Number of pages25
JournalMethods in Enzymology
Volume386
DOIs
StatePublished - Jan 1 2004

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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