Production of Malignant Tumors in Rats with Radioactive Phosphorus


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10 Scopus citations


One of the late effects observed in rats injected with large doses of radioactive phosphorus was the development of malignant neoplasms. Of thirteen tumors, ten were osteogenic sarcomas, situated most frequently in the jaw and also occurring in the spine, tibia, femur, or ilium. Four of the neoplasms metastasized to the lungs. There were three squamous-cell carcinomas involving the face and associated with exophthalmos. The neoplasms occurred in animals which received (a) a single LD50dose of P32 (average latent period of 290 days) and (b) repeated doses of 1.5 μc. per gram of P32 (average latent period of 165 days). The incidence of tumor development was about 4C per cent. Atypical proliferation of bone was usually found in these rats, and the lesions may have served as a precursor to malignant change.

Original languageEnglish (US)
Pages (from-to)129-138
Number of pages10
JournalCancer Research
Issue number3
StatePublished - Mar 1 1950

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    KOLETSKY, S., BONTE, F. J., & FRIEDELL, H. L. (1950). Production of Malignant Tumors in Rats with Radioactive Phosphorus. Cancer Research, 10(3), 129-138.