TY - JOUR
T1 - Profile of Chronic and Recurrent Angina Pectoris in a Referral Population
AU - Alexander, Karen P.
AU - Cowper, Patricia A.
AU - Kempf, Judith A.
AU - Lytle, Barbara L.
AU - Peterson, Eric D.
N1 - Funding Information:
Research supported by CV Therapeutics and a Paul Beeson Career Development Award (American Federation for Aging Research, New York, New York; Peterson, principal investigator). Karen Alexander, Eric Peterson, and Patricia Cowper received funding for this project through an unrestricted research grant from CV Therapeutics. Judith Kempf is an employee of CV Therapeutics as the Director of Outcomes Research.
PY - 2008/11/15
Y1 - 2008/11/15
N2 - Angina pectoris (AP) often responds to treatment, but in some, it becomes chronic or recurs over time. Identifying patients with continued AP is a necessary to understand its associations and implications. A baseline cohort with coronary disease and AP were surveyed 6 months and 1 year after catheterization for self-reported symptoms and quality of life. Patients were divided into 3 groups: chronic AP, recurrent AP, and AP free. Baseline characteristics, medications, revascularization, and quality of life are described. Regression analysis determined independent associations with chronic AP. Of the 1,109 patients with complete 1-year follow-up, 19% (n = 207) had chronic AP, 11% (n = 126) had recurrent AP, but most (70%, n = 776) were AP free. Patients with chronic and recurrent AP had similar cardiac histories, had more single vessel coronary disease, and underwent revascularization less often. Patients with recurrent AP had lower educational status and more often smoked. Patients with chronic AP were younger, were women, had higher body mass index, had more depression and lung disease, and had more frequent baseline AP. They also took more antianginals and other medications and had reduced physical function and health-related quality of life in relation to the persistence and frequency of symptoms (p <0.001). In conclusion, patients with chronic and recurrent AP represent unique populations in whom AP continues to negatively impact quality of life despite contemporary care.
AB - Angina pectoris (AP) often responds to treatment, but in some, it becomes chronic or recurs over time. Identifying patients with continued AP is a necessary to understand its associations and implications. A baseline cohort with coronary disease and AP were surveyed 6 months and 1 year after catheterization for self-reported symptoms and quality of life. Patients were divided into 3 groups: chronic AP, recurrent AP, and AP free. Baseline characteristics, medications, revascularization, and quality of life are described. Regression analysis determined independent associations with chronic AP. Of the 1,109 patients with complete 1-year follow-up, 19% (n = 207) had chronic AP, 11% (n = 126) had recurrent AP, but most (70%, n = 776) were AP free. Patients with chronic and recurrent AP had similar cardiac histories, had more single vessel coronary disease, and underwent revascularization less often. Patients with recurrent AP had lower educational status and more often smoked. Patients with chronic AP were younger, were women, had higher body mass index, had more depression and lung disease, and had more frequent baseline AP. They also took more antianginals and other medications and had reduced physical function and health-related quality of life in relation to the persistence and frequency of symptoms (p <0.001). In conclusion, patients with chronic and recurrent AP represent unique populations in whom AP continues to negatively impact quality of life despite contemporary care.
UR - http://www.scopus.com/inward/record.url?scp=56349099891&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56349099891&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2008.07.006
DO - 10.1016/j.amjcard.2008.07.006
M3 - Article
C2 - 18993145
AN - SCOPUS:56349099891
SN - 0002-9149
VL - 102
SP - 1301
EP - 1306
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 10
ER -