Progesterone and 5α-pregnane-3,20-dione in peripheral blood of normal young women. Daily measurements throughout the menstrual cycle

Leon Milewich, Celso Gomez-Sanchez, George Crowley, John C. Porter, James D. Madden, Paul C. Macdonald

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The peripheral plasma concentrations of progesterone and 5a-pregnane-3,20-dione were measured daily throughout the ovarian cycle of five presumptively ovulatory women. The concentrations of progesterone and 5α-pregnane-3,20-dione during the follicular phase were 0.11 ± 0.02 ng/ml (mean ± SE) and 0.16 ± 0.01 ng/ml, respectively. In four of these women the concentrations of both progesterone and 5α-pregnane-3,20-dione began to rise immediately after the luteinizing hormone (LH) peak and reached maximal concentrations five to eight days later (progesterone: 8.6 to 19.9 ng/ml; 5α-pregnane-3,20-dione: 1.4 to 2.8 ng/ml). The luteal phases in these women, measured from the day of the LH peak to the onset of the next menses, varied from 13 to 18 days. In the other woman with a late LH surge (day 27 of the cycle) the peak concentrations of progesterone and 5α pregnane- 3,20-dione were reached four days after the LH peak (8.9 ng/ml and 0.8 ng/ml, respectively). The luteal phase in this woman was 11 days. From the results of this study, it appears that the concentrations of 5α-pregnane-3,20-dione in peripheral blood during the luteal phase are proportional to the availability of progesterone as substrate for the 5α-reductase enzyme system.

Original languageEnglish (US)
Pages (from-to)617-622
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume45
Issue number4
DOIs
StatePublished - 1977

Fingerprint

Pregnanes
Menstrual Cycle
Progesterone
Blood
Luteinizing Hormone
Luteal Phase
Follicular Phase
Menstruation
Oxidoreductases
Availability
Plasmas
Substrates
Enzymes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Progesterone and 5α-pregnane-3,20-dione in peripheral blood of normal young women. Daily measurements throughout the menstrual cycle. / Milewich, Leon; Gomez-Sanchez, Celso; Crowley, George; Porter, John C.; Madden, James D.; Macdonald, Paul C.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 45, No. 4, 1977, p. 617-622.

Research output: Contribution to journalArticle

Milewich, Leon ; Gomez-Sanchez, Celso ; Crowley, George ; Porter, John C. ; Madden, James D. ; Macdonald, Paul C. / Progesterone and 5α-pregnane-3,20-dione in peripheral blood of normal young women. Daily measurements throughout the menstrual cycle. In: Journal of Clinical Endocrinology and Metabolism. 1977 ; Vol. 45, No. 4. pp. 617-622.
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AB - The peripheral plasma concentrations of progesterone and 5a-pregnane-3,20-dione were measured daily throughout the ovarian cycle of five presumptively ovulatory women. The concentrations of progesterone and 5α-pregnane-3,20-dione during the follicular phase were 0.11 ± 0.02 ng/ml (mean ± SE) and 0.16 ± 0.01 ng/ml, respectively. In four of these women the concentrations of both progesterone and 5α-pregnane-3,20-dione began to rise immediately after the luteinizing hormone (LH) peak and reached maximal concentrations five to eight days later (progesterone: 8.6 to 19.9 ng/ml; 5α-pregnane-3,20-dione: 1.4 to 2.8 ng/ml). The luteal phases in these women, measured from the day of the LH peak to the onset of the next menses, varied from 13 to 18 days. In the other woman with a late LH surge (day 27 of the cycle) the peak concentrations of progesterone and 5α pregnane- 3,20-dione were reached four days after the LH peak (8.9 ng/ml and 0.8 ng/ml, respectively). The luteal phase in this woman was 11 days. From the results of this study, it appears that the concentrations of 5α-pregnane-3,20-dione in peripheral blood during the luteal phase are proportional to the availability of progesterone as substrate for the 5α-reductase enzyme system.

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