Prognostic factors associated with recurrence in clinical stage I adenocarcinoma

J. R. Lurain, B. L. Rice, A. W. Rademaker, L. E. Poggensee, J. C. Schink, D. S. Miller

Research output: Contribution to journalArticle

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Abstract

Two hundred sixty-four consecutive patients with clinical stage I endometrial adenocarcinoma who underwent primary surgical therapy between July 1979 and August 1988 were followed prospectively and evaluated for disease recurrence for 8-112 months (mean 51.5). Thirty-three patients (12.5%) developed recurrence or died of disease. In univariate statistical analysis, prognostic factors significantly associated with disease recurrence were as follows: age (mean 68.6 years with versus 60.3 years without recurrence; P=.0001); histology (adenocarcinoma 8.8%, adenosquamous 35.7%, papillary 25%, clear-cell 57.1% ; P<.0001); tumor grade (grade 1, 7.7%, grade 2, 10.5%, grade 3, 36.1%; P<.0001); depth of myometrial invasion (none 9.8%, less than one-half 7.4%, one-half or greater 29.6% ; P=.0001); lymph node status (negative 8.3%, positive 47.6%; P<.0001); non-nodal extrauterine disease spread (absent 11.0%, present 50%; P=.0003); peritoneal cytology (negative 9.4%, positive 26.3%; P=.004), and tumor size (2 cm or less 7%, greater than 2 cm 17.3%; P=.05). Cervical extension and uterine size had no significant effect on recurrence. Using multivariate analysis, grade 3 tumor (P=.002), advancing age (P=.004), lymph node metastasis (P=.006), and presence of extrauterine disease spread other than lymph node metastasis (P=.038) were the only variables significantly associated with disease recurrence or death. This study supports the new International Federation of Gynecology and Obstetrics surgical staging system for endometrial cancer. Recurrence developed in 7.4% (15 of 202) of patients with surgical stage I disease, none of seven patients with surgical stage II disease, and 32.7% (18 of 55) of patients with surgical stage III disease (P<.0001).

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalObstetrics and Gynecology
Volume78
Issue number1
StatePublished - 1991

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Adenocarcinoma
Recurrence
Lymph Nodes
Neoplasm Metastasis
Neoplasms
Endometrial Neoplasms
Gynecology
Obstetrics
Cell Biology
Histology
Multivariate Analysis

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Lurain, J. R., Rice, B. L., Rademaker, A. W., Poggensee, L. E., Schink, J. C., & Miller, D. S. (1991). Prognostic factors associated with recurrence in clinical stage I adenocarcinoma. Obstetrics and Gynecology, 78(1), 63-69.

Prognostic factors associated with recurrence in clinical stage I adenocarcinoma. / Lurain, J. R.; Rice, B. L.; Rademaker, A. W.; Poggensee, L. E.; Schink, J. C.; Miller, D. S.

In: Obstetrics and Gynecology, Vol. 78, No. 1, 1991, p. 63-69.

Research output: Contribution to journalArticle

Lurain, JR, Rice, BL, Rademaker, AW, Poggensee, LE, Schink, JC & Miller, DS 1991, 'Prognostic factors associated with recurrence in clinical stage I adenocarcinoma', Obstetrics and Gynecology, vol. 78, no. 1, pp. 63-69.
Lurain JR, Rice BL, Rademaker AW, Poggensee LE, Schink JC, Miller DS. Prognostic factors associated with recurrence in clinical stage I adenocarcinoma. Obstetrics and Gynecology. 1991;78(1):63-69.
Lurain, J. R. ; Rice, B. L. ; Rademaker, A. W. ; Poggensee, L. E. ; Schink, J. C. ; Miller, D. S. / Prognostic factors associated with recurrence in clinical stage I adenocarcinoma. In: Obstetrics and Gynecology. 1991 ; Vol. 78, No. 1. pp. 63-69.
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abstract = "Two hundred sixty-four consecutive patients with clinical stage I endometrial adenocarcinoma who underwent primary surgical therapy between July 1979 and August 1988 were followed prospectively and evaluated for disease recurrence for 8-112 months (mean 51.5). Thirty-three patients (12.5{\%}) developed recurrence or died of disease. In univariate statistical analysis, prognostic factors significantly associated with disease recurrence were as follows: age (mean 68.6 years with versus 60.3 years without recurrence; P=.0001); histology (adenocarcinoma 8.8{\%}, adenosquamous 35.7{\%}, papillary 25{\%}, clear-cell 57.1{\%} ; P<.0001); tumor grade (grade 1, 7.7{\%}, grade 2, 10.5{\%}, grade 3, 36.1{\%}; P<.0001); depth of myometrial invasion (none 9.8{\%}, less than one-half 7.4{\%}, one-half or greater 29.6{\%} ; P=.0001); lymph node status (negative 8.3{\%}, positive 47.6{\%}; P<.0001); non-nodal extrauterine disease spread (absent 11.0{\%}, present 50{\%}; P=.0003); peritoneal cytology (negative 9.4{\%}, positive 26.3{\%}; P=.004), and tumor size (2 cm or less 7{\%}, greater than 2 cm 17.3{\%}; P=.05). Cervical extension and uterine size had no significant effect on recurrence. Using multivariate analysis, grade 3 tumor (P=.002), advancing age (P=.004), lymph node metastasis (P=.006), and presence of extrauterine disease spread other than lymph node metastasis (P=.038) were the only variables significantly associated with disease recurrence or death. This study supports the new International Federation of Gynecology and Obstetrics surgical staging system for endometrial cancer. Recurrence developed in 7.4{\%} (15 of 202) of patients with surgical stage I disease, none of seven patients with surgical stage II disease, and 32.7{\%} (18 of 55) of patients with surgical stage III disease (P<.0001).",
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T1 - Prognostic factors associated with recurrence in clinical stage I adenocarcinoma

AU - Lurain, J. R.

AU - Rice, B. L.

AU - Rademaker, A. W.

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AU - Schink, J. C.

AU - Miller, D. S.

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N2 - Two hundred sixty-four consecutive patients with clinical stage I endometrial adenocarcinoma who underwent primary surgical therapy between July 1979 and August 1988 were followed prospectively and evaluated for disease recurrence for 8-112 months (mean 51.5). Thirty-three patients (12.5%) developed recurrence or died of disease. In univariate statistical analysis, prognostic factors significantly associated with disease recurrence were as follows: age (mean 68.6 years with versus 60.3 years without recurrence; P=.0001); histology (adenocarcinoma 8.8%, adenosquamous 35.7%, papillary 25%, clear-cell 57.1% ; P<.0001); tumor grade (grade 1, 7.7%, grade 2, 10.5%, grade 3, 36.1%; P<.0001); depth of myometrial invasion (none 9.8%, less than one-half 7.4%, one-half or greater 29.6% ; P=.0001); lymph node status (negative 8.3%, positive 47.6%; P<.0001); non-nodal extrauterine disease spread (absent 11.0%, present 50%; P=.0003); peritoneal cytology (negative 9.4%, positive 26.3%; P=.004), and tumor size (2 cm or less 7%, greater than 2 cm 17.3%; P=.05). Cervical extension and uterine size had no significant effect on recurrence. Using multivariate analysis, grade 3 tumor (P=.002), advancing age (P=.004), lymph node metastasis (P=.006), and presence of extrauterine disease spread other than lymph node metastasis (P=.038) were the only variables significantly associated with disease recurrence or death. This study supports the new International Federation of Gynecology and Obstetrics surgical staging system for endometrial cancer. Recurrence developed in 7.4% (15 of 202) of patients with surgical stage I disease, none of seven patients with surgical stage II disease, and 32.7% (18 of 55) of patients with surgical stage III disease (P<.0001).

AB - Two hundred sixty-four consecutive patients with clinical stage I endometrial adenocarcinoma who underwent primary surgical therapy between July 1979 and August 1988 were followed prospectively and evaluated for disease recurrence for 8-112 months (mean 51.5). Thirty-three patients (12.5%) developed recurrence or died of disease. In univariate statistical analysis, prognostic factors significantly associated with disease recurrence were as follows: age (mean 68.6 years with versus 60.3 years without recurrence; P=.0001); histology (adenocarcinoma 8.8%, adenosquamous 35.7%, papillary 25%, clear-cell 57.1% ; P<.0001); tumor grade (grade 1, 7.7%, grade 2, 10.5%, grade 3, 36.1%; P<.0001); depth of myometrial invasion (none 9.8%, less than one-half 7.4%, one-half or greater 29.6% ; P=.0001); lymph node status (negative 8.3%, positive 47.6%; P<.0001); non-nodal extrauterine disease spread (absent 11.0%, present 50%; P=.0003); peritoneal cytology (negative 9.4%, positive 26.3%; P=.004), and tumor size (2 cm or less 7%, greater than 2 cm 17.3%; P=.05). Cervical extension and uterine size had no significant effect on recurrence. Using multivariate analysis, grade 3 tumor (P=.002), advancing age (P=.004), lymph node metastasis (P=.006), and presence of extrauterine disease spread other than lymph node metastasis (P=.038) were the only variables significantly associated with disease recurrence or death. This study supports the new International Federation of Gynecology and Obstetrics surgical staging system for endometrial cancer. Recurrence developed in 7.4% (15 of 202) of patients with surgical stage I disease, none of seven patients with surgical stage II disease, and 32.7% (18 of 55) of patients with surgical stage III disease (P<.0001).

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