Prognostic Genetic Signatures in Upper Tract Urothelial Carcinoma

Qiang Li, Aditya Bagrodia, Eugene K. Cha, Jonathan A. Coleman

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Urothelial carcinoma is a highly heterogeneous disease that can arise throughout the entire urothelial lining from the renal pelvis to the proximal urethra. Upper tract urothelial carcinoma (UTUC) is rare, and while it shares many similarities with urothelial carcinoma of bladder (UCB), there are also significant differences between UTUC and UCB regarding clinical management and outcomes. No major advances have been made recently in the development of new systemic therapies for urothelial carcinoma, partly due to the lack of understanding of underlying molecular pathogenetic mechanisms. In the past decade, the emergence of next-generation sequencing has greatly enabled genomic characterization of tumor samples. Researchers are currently exploring a personalized approach to augment traditional clinical decision-making based on genetic alterations. In the present review, we summarize current genomic advances in UTUC and discuss the potential implications of these developments for developing prognostic and predictive biomarkers.

Original languageEnglish (US)
Article number12
Pages (from-to)1-8
Number of pages8
JournalCurrent Urology Reports
Volume17
Issue number2
DOIs
StatePublished - Feb 1 2016

Keywords

  • Biomarkers
  • Genomics
  • Prediction
  • Upper tract urothelial carcinoma

ASJC Scopus subject areas

  • Urology

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