Prognostic significance of high-sensitivity cardiac troponin T concentrations between the limit of blank and limit of detection in community-dwelling adults: A metaanalysis

Ravi H. Parikh, Stephen L. Seliger, James A de Lemos, Vijay Nambi, Robert Christenson, Colby Ayers, Wensheng Sun, John S. Gottdiener, Lewis H. Kuller, Christie Ballantyne, Christopher R. DeFilippi

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23 Scopus citations

Abstract

BACKGROUND: There is controversy regarding whether to report concentrations of high-sensitivity cardiac troponin T (hs-cTnT) to the limit of blank (LOB) (3 ng/L) or the limit of detection (LOD) (5 ng/L) of the assay in community-based cohorts. We hypothesized that hscTnT concentrations between the LOB and LOD would be associated with poorer cardiovascular outcomes compared to concentrations below the LOB. METHODS: hs-cTnT was analyzed in a total of 10 723 participants from the Cardiovascular Health Study (CHS), Atherosclerosis Risk in Communities (ARIC) study, and Dallas Heart Study (DHS). Participants were divided into 2 groups, those with hs-cTnT concentrations below the limit of blank (LOB) (

Original languageEnglish (US)
Pages (from-to)1524-1531
Number of pages8
JournalClinical Chemistry
Volume61
Issue number12
DOIs
StatePublished - Dec 1 2015

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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    Parikh, R. H., Seliger, S. L., de Lemos, J. A., Nambi, V., Christenson, R., Ayers, C., Sun, W., Gottdiener, J. S., Kuller, L. H., Ballantyne, C., & DeFilippi, C. R. (2015). Prognostic significance of high-sensitivity cardiac troponin T concentrations between the limit of blank and limit of detection in community-dwelling adults: A metaanalysis. Clinical Chemistry, 61(12), 1524-1531. https://doi.org/10.1373/clinchem.2015.244160