Prognostic significance of high-sensitivity cardiac troponin T concentrations between the limit of blank and limit of detection in community-dwelling adults: A metaanalysis

Ravi H. Parikh, Stephen L. Seliger, James A de Lemos, Vijay Nambi, Robert Christenson, Colby Ayers, Wensheng Sun, John S. Gottdiener, Lewis H. Kuller, Christie Ballantyne, Christopher R. DeFilippi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

BACKGROUND: There is controversy regarding whether to report concentrations of high-sensitivity cardiac troponin T (hs-cTnT) to the limit of blank (LOB) (3 ng/L) or the limit of detection (LOD) (5 ng/L) of the assay in community-based cohorts. We hypothesized that hscTnT concentrations between the LOB and LOD would be associated with poorer cardiovascular outcomes compared to concentrations below the LOB. METHODS: hs-cTnT was analyzed in a total of 10 723 participants from the Cardiovascular Health Study (CHS), Atherosclerosis Risk in Communities (ARIC) study, and Dallas Heart Study (DHS). Participants were divided into 2 groups, those with hs-cTnT concentrations below the limit of blank (LOB) (

Original languageEnglish (US)
Pages (from-to)1524-1531
Number of pages8
JournalClinical Chemistry
Volume61
Issue number12
DOIs
StatePublished - Dec 1 2015

Fingerprint

Independent Living
Troponin T
Limit of Detection
Assays
Atherosclerosis
Health

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Prognostic significance of high-sensitivity cardiac troponin T concentrations between the limit of blank and limit of detection in community-dwelling adults : A metaanalysis. / Parikh, Ravi H.; Seliger, Stephen L.; de Lemos, James A; Nambi, Vijay; Christenson, Robert; Ayers, Colby; Sun, Wensheng; Gottdiener, John S.; Kuller, Lewis H.; Ballantyne, Christie; DeFilippi, Christopher R.

In: Clinical Chemistry, Vol. 61, No. 12, 01.12.2015, p. 1524-1531.

Research output: Contribution to journalArticle

Parikh, RH, Seliger, SL, de Lemos, JA, Nambi, V, Christenson, R, Ayers, C, Sun, W, Gottdiener, JS, Kuller, LH, Ballantyne, C & DeFilippi, CR 2015, 'Prognostic significance of high-sensitivity cardiac troponin T concentrations between the limit of blank and limit of detection in community-dwelling adults: A metaanalysis', Clinical Chemistry, vol. 61, no. 12, pp. 1524-1531. https://doi.org/10.1373/clinchem.2015.244160
Parikh, Ravi H. ; Seliger, Stephen L. ; de Lemos, James A ; Nambi, Vijay ; Christenson, Robert ; Ayers, Colby ; Sun, Wensheng ; Gottdiener, John S. ; Kuller, Lewis H. ; Ballantyne, Christie ; DeFilippi, Christopher R. / Prognostic significance of high-sensitivity cardiac troponin T concentrations between the limit of blank and limit of detection in community-dwelling adults : A metaanalysis. In: Clinical Chemistry. 2015 ; Vol. 61, No. 12. pp. 1524-1531.
@article{dd9c7af0f8bf43b39ac4178f994b2bce,
title = "Prognostic significance of high-sensitivity cardiac troponin T concentrations between the limit of blank and limit of detection in community-dwelling adults: A metaanalysis",
abstract = "BACKGROUND: There is controversy regarding whether to report concentrations of high-sensitivity cardiac troponin T (hs-cTnT) to the limit of blank (LOB) (3 ng/L) or the limit of detection (LOD) (5 ng/L) of the assay in community-based cohorts. We hypothesized that hscTnT concentrations between the LOB and LOD would be associated with poorer cardiovascular outcomes compared to concentrations below the LOB. METHODS: hs-cTnT was analyzed in a total of 10 723 participants from the Cardiovascular Health Study (CHS), Atherosclerosis Risk in Communities (ARIC) study, and Dallas Heart Study (DHS). Participants were divided into 2 groups, those with hs-cTnT concentrations below the limit of blank (LOB) (",
author = "Parikh, {Ravi H.} and Seliger, {Stephen L.} and {de Lemos}, {James A} and Vijay Nambi and Robert Christenson and Colby Ayers and Wensheng Sun and Gottdiener, {John S.} and Kuller, {Lewis H.} and Christie Ballantyne and DeFilippi, {Christopher R.}",
year = "2015",
month = "12",
day = "1",
doi = "10.1373/clinchem.2015.244160",
language = "English (US)",
volume = "61",
pages = "1524--1531",
journal = "Clinical Chemistry",
issn = "0009-9147",
publisher = "American Association for Clinical Chemistry Inc.",
number = "12",

}

TY - JOUR

T1 - Prognostic significance of high-sensitivity cardiac troponin T concentrations between the limit of blank and limit of detection in community-dwelling adults

T2 - A metaanalysis

AU - Parikh, Ravi H.

AU - Seliger, Stephen L.

AU - de Lemos, James A

AU - Nambi, Vijay

AU - Christenson, Robert

AU - Ayers, Colby

AU - Sun, Wensheng

AU - Gottdiener, John S.

AU - Kuller, Lewis H.

AU - Ballantyne, Christie

AU - DeFilippi, Christopher R.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - BACKGROUND: There is controversy regarding whether to report concentrations of high-sensitivity cardiac troponin T (hs-cTnT) to the limit of blank (LOB) (3 ng/L) or the limit of detection (LOD) (5 ng/L) of the assay in community-based cohorts. We hypothesized that hscTnT concentrations between the LOB and LOD would be associated with poorer cardiovascular outcomes compared to concentrations below the LOB. METHODS: hs-cTnT was analyzed in a total of 10 723 participants from the Cardiovascular Health Study (CHS), Atherosclerosis Risk in Communities (ARIC) study, and Dallas Heart Study (DHS). Participants were divided into 2 groups, those with hs-cTnT concentrations below the limit of blank (LOB) (

AB - BACKGROUND: There is controversy regarding whether to report concentrations of high-sensitivity cardiac troponin T (hs-cTnT) to the limit of blank (LOB) (3 ng/L) or the limit of detection (LOD) (5 ng/L) of the assay in community-based cohorts. We hypothesized that hscTnT concentrations between the LOB and LOD would be associated with poorer cardiovascular outcomes compared to concentrations below the LOB. METHODS: hs-cTnT was analyzed in a total of 10 723 participants from the Cardiovascular Health Study (CHS), Atherosclerosis Risk in Communities (ARIC) study, and Dallas Heart Study (DHS). Participants were divided into 2 groups, those with hs-cTnT concentrations below the limit of blank (LOB) (

UR - http://www.scopus.com/inward/record.url?scp=84948671082&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948671082&partnerID=8YFLogxK

U2 - 10.1373/clinchem.2015.244160

DO - 10.1373/clinchem.2015.244160

M3 - Article

C2 - 26506994

AN - SCOPUS:84948671082

VL - 61

SP - 1524

EP - 1531

JO - Clinical Chemistry

JF - Clinical Chemistry

SN - 0009-9147

IS - 12

ER -