Prognostic significance of NADPH quinine oxidoreductase 1 overexpression in head and neck squamous cell carcinoma

Yang Yang, Jin Tiefeng, Liu Shuangping, Chen Liyan, Lin Lijuan, Han Hongxiu, Li Longshan, Lin Zhenhua

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To investigate the significance of NADPH quinine oxidoreductase 1 (NQ01) protein overexpression on prognostic evaluation of head and neck squamous cell carcinoma (HNSCC). Methods: NQ01 protein was detected in 162 of HNSCC, 45 cases of adjacent nontumor tissues and 26 samples of normal head and neck epithelia using EnVision immunohistochemical. Correlation between NQ01 overexpression and patients prognosis was also analyzed. Results: The positive rate and strongly positive rate of NQOl protein were 84. 0% (136/162) and 69. 8% (113/162) in HNSCC, respectively, and both of which were significantly higher than either those in adjacent nontumor tissues and normal head and neck epithelia (both P < 0. 01). NQOl expression was significantly correlated with the clinical stage, pT and chemoradiotherapy of HNSCC (P<0. 01). Kaplan-Meier survival analysis showed that overall survival and disease-free survival rates were significantly higher in HNSCC patients with high level NQOl expression than that those with low level of NQ01 expression (Log-rank = 6. 625, P = 0. 010; Log-rank = 6. 234, P = 0.013). Additional analysis by Cox proportional hazard regression model showed that high level of NQOl expression was an independent hazard predictor for overall survival of patients with HNSCC (Wald = 6. 626, P = 0. 008). Conclusions: NQOl expression level is closely correlated with the progression and prognosis of patients with HNSCC. High level of NQOl expression may be used as an important indicator for patients with poor prognostic HNSCC.

Original languageEnglish (US)
Pages (from-to)463-467
Number of pages5
JournalChinese Journal of Pathology
Volume43
Issue number7
DOIs
StatePublished - Jul 8 2014

Fingerprint

Quinine
NADP
Oxidoreductases
Neck
Epithelium
Head
Proteins
Survival
Carcinoma, squamous cell of head and neck
Kaplan-Meier Estimate
Chemoradiotherapy
Survival Analysis
Proportional Hazards Models
Disease-Free Survival
Survival Rate

Keywords

  • Disease-free survival
  • Head and neck neoplasms
  • Immunohistochemistry
  • Prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Prognostic significance of NADPH quinine oxidoreductase 1 overexpression in head and neck squamous cell carcinoma. / Yang, Yang; Tiefeng, Jin; Shuangping, Liu; Liyan, Chen; Lijuan, Lin; Hongxiu, Han; Longshan, Li; Zhenhua, Lin.

In: Chinese Journal of Pathology, Vol. 43, No. 7, 08.07.2014, p. 463-467.

Research output: Contribution to journalArticle

Yang, Yang ; Tiefeng, Jin ; Shuangping, Liu ; Liyan, Chen ; Lijuan, Lin ; Hongxiu, Han ; Longshan, Li ; Zhenhua, Lin. / Prognostic significance of NADPH quinine oxidoreductase 1 overexpression in head and neck squamous cell carcinoma. In: Chinese Journal of Pathology. 2014 ; Vol. 43, No. 7. pp. 463-467.
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abstract = "Objective: To investigate the significance of NADPH quinine oxidoreductase 1 (NQ01) protein overexpression on prognostic evaluation of head and neck squamous cell carcinoma (HNSCC). Methods: NQ01 protein was detected in 162 of HNSCC, 45 cases of adjacent nontumor tissues and 26 samples of normal head and neck epithelia using EnVision immunohistochemical. Correlation between NQ01 overexpression and patients prognosis was also analyzed. Results: The positive rate and strongly positive rate of NQOl protein were 84. 0{\%} (136/162) and 69. 8{\%} (113/162) in HNSCC, respectively, and both of which were significantly higher than either those in adjacent nontumor tissues and normal head and neck epithelia (both P < 0. 01). NQOl expression was significantly correlated with the clinical stage, pT and chemoradiotherapy of HNSCC (P<0. 01). Kaplan-Meier survival analysis showed that overall survival and disease-free survival rates were significantly higher in HNSCC patients with high level NQOl expression than that those with low level of NQ01 expression (Log-rank = 6. 625, P = 0. 010; Log-rank = 6. 234, P = 0.013). Additional analysis by Cox proportional hazard regression model showed that high level of NQOl expression was an independent hazard predictor for overall survival of patients with HNSCC (Wald = 6. 626, P = 0. 008). Conclusions: NQOl expression level is closely correlated with the progression and prognosis of patients with HNSCC. High level of NQOl expression may be used as an important indicator for patients with poor prognostic HNSCC.",
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T1 - Prognostic significance of NADPH quinine oxidoreductase 1 overexpression in head and neck squamous cell carcinoma

AU - Yang, Yang

AU - Tiefeng, Jin

AU - Shuangping, Liu

AU - Liyan, Chen

AU - Lijuan, Lin

AU - Hongxiu, Han

AU - Longshan, Li

AU - Zhenhua, Lin

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N2 - Objective: To investigate the significance of NADPH quinine oxidoreductase 1 (NQ01) protein overexpression on prognostic evaluation of head and neck squamous cell carcinoma (HNSCC). Methods: NQ01 protein was detected in 162 of HNSCC, 45 cases of adjacent nontumor tissues and 26 samples of normal head and neck epithelia using EnVision immunohistochemical. Correlation between NQ01 overexpression and patients prognosis was also analyzed. Results: The positive rate and strongly positive rate of NQOl protein were 84. 0% (136/162) and 69. 8% (113/162) in HNSCC, respectively, and both of which were significantly higher than either those in adjacent nontumor tissues and normal head and neck epithelia (both P < 0. 01). NQOl expression was significantly correlated with the clinical stage, pT and chemoradiotherapy of HNSCC (P<0. 01). Kaplan-Meier survival analysis showed that overall survival and disease-free survival rates were significantly higher in HNSCC patients with high level NQOl expression than that those with low level of NQ01 expression (Log-rank = 6. 625, P = 0. 010; Log-rank = 6. 234, P = 0.013). Additional analysis by Cox proportional hazard regression model showed that high level of NQOl expression was an independent hazard predictor for overall survival of patients with HNSCC (Wald = 6. 626, P = 0. 008). Conclusions: NQOl expression level is closely correlated with the progression and prognosis of patients with HNSCC. High level of NQOl expression may be used as an important indicator for patients with poor prognostic HNSCC.

AB - Objective: To investigate the significance of NADPH quinine oxidoreductase 1 (NQ01) protein overexpression on prognostic evaluation of head and neck squamous cell carcinoma (HNSCC). Methods: NQ01 protein was detected in 162 of HNSCC, 45 cases of adjacent nontumor tissues and 26 samples of normal head and neck epithelia using EnVision immunohistochemical. Correlation between NQ01 overexpression and patients prognosis was also analyzed. Results: The positive rate and strongly positive rate of NQOl protein were 84. 0% (136/162) and 69. 8% (113/162) in HNSCC, respectively, and both of which were significantly higher than either those in adjacent nontumor tissues and normal head and neck epithelia (both P < 0. 01). NQOl expression was significantly correlated with the clinical stage, pT and chemoradiotherapy of HNSCC (P<0. 01). Kaplan-Meier survival analysis showed that overall survival and disease-free survival rates were significantly higher in HNSCC patients with high level NQOl expression than that those with low level of NQ01 expression (Log-rank = 6. 625, P = 0. 010; Log-rank = 6. 234, P = 0.013). Additional analysis by Cox proportional hazard regression model showed that high level of NQOl expression was an independent hazard predictor for overall survival of patients with HNSCC (Wald = 6. 626, P = 0. 008). Conclusions: NQOl expression level is closely correlated with the progression and prognosis of patients with HNSCC. High level of NQOl expression may be used as an important indicator for patients with poor prognostic HNSCC.

KW - Disease-free survival

KW - Head and neck neoplasms

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KW - Prognosis

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