Prognostic Value of Leptin Receptor Overexpression in Upper Tract Urothelial Carcinomas in Taiwan

Yi Chen Lee, Wen Jeng Wu, Hui Hui Lin, Wei Ming Li, Chun Nung Huang, Wei Chi Hsu, Lin Li Chang, Ching Chia Li, Hsin Chih Yeh, Chien Feng Li, Hung Lung Ke

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Leptin receptor is involved in cancer development and progression. We examined leptin receptor expression in upper tract urothelial carcinoma by immunohistochemistry. Leptin receptor expression could predict patient survival. Objectives Leptin and its receptor (LEPR) are key players in the regulation of energy balance and body weight control and act as a growth factor for specific organs in both normal and disease states. However, LEPR accumulation may be involved in carcinogenesis, progression, and metastasis in many cancers. This study evaluated the clinical significance of LEPR expression in upper tract urothelial carcinoma (UTUC). Materials and Methods LEPR expression was examined in 110 tissue samples from patients with UTUC, using immunohistochemistry, and an analysis was performed to identify evidence of association between LEPR expression and different clinicopathologic variables. Results LEPR expression was significantly correlated with patients with increased body mass index (P < .001) and high serum creatinine levels (P = .005). We found, using the log-rank test, that high LEPR expression was associated with poor recurrence-free (P = .009) and cancer-specific survival (P = .001). This finding was supported by our results using Cox regression analysis, which showed that LEPR expression was an independent predictor of poor recurrence-free survival (hazard ratio = 2.55; P = .011) and cancer-specific survival (hazard ratio = 2.26; P = .006). Conclusions Our findings indicate that LEPR expression is a potential biomarker for predicting patient survival in UTUC. Further study is necessary to investigate the role of LEPR in carcinogenesis of UTUC.

Original languageEnglish (US)
Pages (from-to)e653-e659
JournalClinical Genitourinary Cancer
Volume15
Issue number4
DOIs
StatePublished - Aug 2017
Externally publishedYes

Keywords

  • BMI
  • Immunohistochemistry (IHC)
  • Obesity
  • Renal pelvis cancer
  • Ureter cancer

ASJC Scopus subject areas

  • Oncology
  • Urology

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