Prognostic value of masked uncontrolled hypertension systematic review and meta-analysis

Sante D. Pierdomenico, Anna M. Pierdomenico, Francesca Coccina, Denis L. Clement, Marc L. De Buyzere, Dirk A. De Bacquer, Iddo Z. Ben-Dov, Wanpen Vongpatanasin, José R. Banegas, Luis M. Ruilope, Lutgarde Thijs, Jan A. Staessen

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


The prognostic relevance of masked uncontrolled hypertension (MUCH) is incompletely clear, and its global impact on cardiovascular outcomes and mortality has not been assessed. The aim of this study was to perform a metaanalysis on the prognostic value of MUCH. We searched for articles assessing outcome in patients with MUCH compared with those with controlled hypertension (CH) and reporting adjusted hazard ratio and 95% CI. We identified 6 studies using ambulatory blood pressure monitoring (12 610 patients with 933 events) and 5 using home blood pressure measurement (17 742 patients with 394 events). The global population included 30 352 patients who experienced 1327 events. Selected studies had cardiovascular outcomes and all-cause mortality as primary outcome, and the main result is a composite of these events. The overall adjusted hazard ratio was 1.80 (95% CI, 1.57-2.06) for MUCH versus CH. Subgroup meta-analysis showed that adjusted hazard ratio was 1.83 (95% CI, 1.52-2.21) in studies using ambulatory blood pressure monitoring and 1.75 (95% CI, 1.38-2.20) in those using home blood pressure measurement. Risk was significantly higher in MUCH than in CH independently of follow-up length and types of studied events. MUCH was at significantly higher risk than CH in all ethnic groups, but the highest hazard ratio was found in studies, including black patients. Risk of cardiovascular events and all-cause mortality is significantly higher in patients with MUCH than in those with CH. MUCH detected by ambulatory or home blood pressure measurement seems to convey similar prognostic information.

Original languageEnglish (US)
Pages (from-to)862-869
Number of pages8
Issue number4
StatePublished - 2018


  • Blood pressure
  • Hypertension
  • Masked hypertension
  • Mortality
  • Risk

ASJC Scopus subject areas

  • Internal Medicine


Dive into the research topics of 'Prognostic value of masked uncontrolled hypertension systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this