Programmed necrosis: Backup to and competitor with apoptosis in the immune system

Jiahuai Han, Chuan Qi Zhong, Duan Wu Zhang

Research output: Contribution to journalReview article

209 Citations (Scopus)

Abstract

Programmed cell death is essential for the development and maintenance of the immune system and its responses to exogenous and endogenous stimuli. Studies have demonstrated that in addition to caspase-dependent apoptosis, necrosis dependent on the kinases RIP1 and RIP3 (also called necroptosis) is a major programmed cell-death pathway in development and immunity. These two programmed cell-death pathways may suppress each other, and necroptosis also serves as an alternative when caspase-dependent apoptosis is inhibited or absent. Here we summarize recent advancements that have identified the molecular mechanisms that underlie necroptosis and explore the mechanisms that regulate the interplay between apoptosis and necroptosis.

Original languageEnglish (US)
Pages (from-to)1143-1149
Number of pages7
JournalNature Immunology
Volume12
Issue number12
DOIs
StatePublished - Dec 1 2011

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Immune System
Cell Death
Necrosis
Apoptosis
Caspases
Immunity
Phosphotransferases
Maintenance

ASJC Scopus subject areas

  • Immunology

Cite this

Programmed necrosis : Backup to and competitor with apoptosis in the immune system. / Han, Jiahuai; Zhong, Chuan Qi; Zhang, Duan Wu.

In: Nature Immunology, Vol. 12, No. 12, 01.12.2011, p. 1143-1149.

Research output: Contribution to journalReview article

Han, Jiahuai ; Zhong, Chuan Qi ; Zhang, Duan Wu. / Programmed necrosis : Backup to and competitor with apoptosis in the immune system. In: Nature Immunology. 2011 ; Vol. 12, No. 12. pp. 1143-1149.
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