Progranulin: A proteolytically processed protein at the crossroads of inflammation and neurodegeneration

Basar Cenik, Chantelle F. Sephton, Bercin Kutluk Cenik, Joachim Herz, Gang Yu

Research output: Contribution to journalShort survey

116 Scopus citations


GRN mutations cause frontotemporal lobar degeneration with TDP-43-positive inclusions. The mechanism of pathogenesis is haploinsufficiency. Recently, homozygous GRN mutations were detected in two patients with neuronal ceroid lipofuscinosis, a lysosomal storage disease. It is unknown whether the pathogenesis of these two conditions is related. Progranulin is cleaved into smaller peptides called granulins. Progranulin and granulins are attributed with roles in cancer, inflammation, and neuronal physiology. Cell surface receptors for progranulin, but not granulin peptides, have been reported. Revealing the cell surface receptors and the intracellular functions of granulins and progranulin is crucial for understanding their contributions to neurodegeneration.

Original languageEnglish (US)
Pages (from-to)32298-32306
Number of pages9
JournalJournal of Biological Chemistry
Issue number39
StatePublished - Sep 21 2012


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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