Progress in nicotinic receptor structural biology

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Here we begin by briefly reviewing landmark structural studies on the nicotinic acetylcholine receptor. We highlight challenges that had to be overcome to push through resolution barriers, then focus on what has been gleaned in the past few years from crystallographic and single particle cryo-EM studies of different nicotinic receptor subunit assemblies and ligand complexes. We discuss insights into ligand recognition, ion permeation, and allosteric gating. We then highlight some foundational aspects of nicotinic receptor structural biology that remain unresolved and are areas ripe for future exploration.

Original languageEnglish (US)
Article number108086
StatePublished - Jul 2020


  • Cryo-EM
  • Nicotine
  • Nicotinic acetylcholine receptor
  • Structural biology

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience


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