Progress in the management of paraneoplastic neurological disorders

Hamid Sadeghian, Steven Vernino

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Paraneoplastic neurological disorders (PNDs) are a rare and diverse group of neurological conditions that can involve any part of the nervous system. Diagnosis is facilitated by finding well-recognized autoantibodies directed against neural antigens in the sera and the cerebrospinal fluid. Identifying and eliminating the underlying malignancy is the mainstay of treatment. Immunomodulatory treatment is gaining more acceptance especially, where a malignancy could not be identified, oncology treatment is completed, or along with cancer treatment. Literature review shows only a handful of systematic prospective case series. Multicenter, prospective controlled clinical trials are needed for future therapeutic advances.

Original languageEnglish (US)
Pages (from-to)43-52
Number of pages10
JournalTherapeutic Advances in Neurological Disorders
Volume3
Issue number1
DOIs
StatePublished - Jan 2010

Keywords

  • cyclophosphamide
  • intravenous immunoglobulin
  • limbic encephalitis
  • neuroimmunology
  • plasma exchange

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology

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