Progress in understanding the molecular pathogenesis of human lung cancer

Yoshitaka Sekido, Kwun M. Fong, John D. Minna

Research output: Contribution to journalArticle

290 Scopus citations

Abstract

We review the molecular pathogenesis of lung cancer including alterations in dominant oncogenes, recessive oncogenes/tumor suppressor genes, alterations in growth regulatory signaling pathways, abnormalities in other pathways, such as apoptosis, autocrine and paracrine growth stimulatory loops, angiogenesis, and host immune responses, other mechanisms of genetic changes, such as microsatellite and methylation alterations, and the potential for inherited predisposition to lung cancer. These changes are related to multistage carcinogenesis involving preneoplastic lesions, and lung development and differentiation. The translational applications of these findings for developing new ways of early detection, prevention, treatment, and prognosis of lung cancer are discussed.

Original languageEnglish (US)
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1378
Issue number1
DOIs
Publication statusPublished - Aug 19 1998

    Fingerprint

Keywords

  • 3p
  • Anergy
  • Angioge nesis
  • Apoptosis
  • Autocrine
  • BCL2
  • Cell cycle
  • Dominant oncogene
  • Early detection
  • Lung cancer
  • Microsatellite alteration
  • MYC
  • p16
  • Paracrine
  • Preneoplasia
  • Prevention
  • Prognosis
  • RAS
  • RB
  • Recessive oncogene
  • Signal transduction
  • Smoking
  • Telomerase
  • TP53
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Biophysics

Cite this