Progress toward a microradiation therapy small animal conformal irradiator

Strahinja Stojadinovic, Daniel A. Low, Milos Vicic, Sasa Mutic, Joseph O. Deasy, Andrew J. Hope, Parag J. Parikh, Perry W. Grigsby

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Microradiation therapy (microRT) systems are being designed to provide conformal radiation therapy to small animals enabling quantitative radiation response evaluation. We used a Monte Carlo approach to estimate the radiation dose distributions from proposed blueprints and developed a beam model to aid in the microRT system design process. This process was applied to a prototype irradiator that uses a small (3 mm long and 3 mm in diameter), cylindrical, high-activity 192Ir source delivering the radiation beam using custom-fabricated tungsten collimators. The BEAMnrc Monte Carlo code was used to simulate dose distributions from these prototype collimators. Simulations were performed at three source-to-surface distances (50, 60, and 70 mm), and with five circular field sizes (5, 7.5, 10, 12.5, and 15 mm). A dose to a 50 X 50 X 50 mm3 water phantom with 1 X 1 X 1 mm3 voxel spacing was computed. A multiparameter dose calculation algorithm was developed to efficiently and accurately calculate doses for treatment planning exercises. The parametrization was selected so that the parameters varied smoothly as a function of depth, source-to-surface distance, and field size, allowing interpolation for geometries that were not simulated using the Monte Carlo simulation. Direct comparison of the model with the Monte Carlo simulations showed that the variations were within 5% error for field sizes larger than 10 mm, and up to 10% for smaller field sizes.

Original languageEnglish (US)
Pages (from-to)3834-3845
Number of pages12
JournalMedical physics
Volume33
Issue number10
DOIs
StatePublished - Jan 1 2006

Keywords

  • 3D dose distribution
  • Beam model
  • MicroRT
  • Monte Carlo simulations
  • Small animal radiation therapy

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Stojadinovic, S., Low, D. A., Vicic, M., Mutic, S., Deasy, J. O., Hope, A. J., Parikh, P. J., & Grigsby, P. W. (2006). Progress toward a microradiation therapy small animal conformal irradiator. Medical physics, 33(10), 3834-3845. https://doi.org/10.1118/1.2349693