To the Editor: We were not surprised to read in the article by Ramsay et al. (Jan. 28 issue)1 that restoration of metabolic control by pancreas transplantation failed to halt the progression of diabetic retinopathy. Most of the patients, to judge from the description given in the paper, must have had advanced and theoretically irreversible diabetic retinopathy. Furthermore, it is conceivable that even if hyperglycemia is necessary for the development of diabetic microvascular complications, individual genetic susceptibility in response to the metabolic derangements varies considerably.2 We would like to point out one misquotation in the discussion of the paper. The.
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