Progressive adaptation in regional parenchyma mechanics following extensive lung resection assessed by functional computed tomography

Cuneyt Yilmaz, Nicholas J. Tustison, D. Merrill Dane, Priya Ravikumar, Masaya Takahashi, James C. Gee, Connie C W Hsia

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In adult canines following major lung resection, the remaining lobes expand asymmetrically, associated with alveolar tissue regrowth, remodeling, and progressive functional compensation over many months. To permit noninvasive longitudinal assessment of regional growth and function, we performed serial high-resolution computed tomography (HRCT) on six male dogs (̃9 mo old, 25.0 ± 4.5 kg, ±SD) at 15 and 30 cmH2O transpulmonary pressure (Ptp) before resection (PRE) and 3 and 15 mo postresection (POST3 and POST15, respectively) of 65-70% of lung units. At POST3, lobar air volume increased 83-148% and tissue (including microvascular blood) volume 120-234% above PRE values without further changes at POST15. Lobar-specific compliance (Cs) increased 52-137% from PRE to POST3 and 28-79% from POST3 to POST15. Inflationrelated parenchyma strain and shear were estimated by detailed registration of corresponding anatomical features at each Ptp. Within each lobe, regional displacement was most pronounced at the caudal region, whereas strain was pronounced in the periphery. Regional three-dimensional strain magnitudes increased heterogeneously from PRE to POST3, with further medial-lateral increases from POST3 to POST15. Lobar principal strains (PSs) were unchanged or modestly elevated postresection; changes in lobar maximum PS correlated inversely with changes in lobar air and tissue volumes. Lobar shear distortion increased in coronal and transverse planes at POST3 without further changes thereafter. These results establish a novel use of functional HRCT to map heterogeneous regional deformation during compensatory lung growth and illustrate a stimulus-response feedback loop whereby postresection mechanical stress initiates differential lobar regrowth and sustained remodeling, which in turn, relieves parenchyma stress and strain, resulting in progressive increases in lobar Cs and a delayed increase in whole lung Cs.

Original languageEnglish (US)
Pages (from-to)1150-1158
Number of pages9
JournalJournal of Applied Physiology
Volume111
Issue number4
DOIs
StatePublished - Oct 2011

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Mechanics
Tomography
Lung
Air
Mechanical Stress
Growth
Blood Volume
Compliance
Canidae
Dogs
Pressure

Keywords

  • Compensatory lung growth
  • CT scan
  • Lung compliance
  • Pneumonectomy
  • Regional deformation
  • Shear

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Progressive adaptation in regional parenchyma mechanics following extensive lung resection assessed by functional computed tomography. / Yilmaz, Cuneyt; Tustison, Nicholas J.; Dane, D. Merrill; Ravikumar, Priya; Takahashi, Masaya; Gee, James C.; Hsia, Connie C W.

In: Journal of Applied Physiology, Vol. 111, No. 4, 10.2011, p. 1150-1158.

Research output: Contribution to journalArticle

Yilmaz, Cuneyt ; Tustison, Nicholas J. ; Dane, D. Merrill ; Ravikumar, Priya ; Takahashi, Masaya ; Gee, James C. ; Hsia, Connie C W. / Progressive adaptation in regional parenchyma mechanics following extensive lung resection assessed by functional computed tomography. In: Journal of Applied Physiology. 2011 ; Vol. 111, No. 4. pp. 1150-1158.
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AB - In adult canines following major lung resection, the remaining lobes expand asymmetrically, associated with alveolar tissue regrowth, remodeling, and progressive functional compensation over many months. To permit noninvasive longitudinal assessment of regional growth and function, we performed serial high-resolution computed tomography (HRCT) on six male dogs (̃9 mo old, 25.0 ± 4.5 kg, ±SD) at 15 and 30 cmH2O transpulmonary pressure (Ptp) before resection (PRE) and 3 and 15 mo postresection (POST3 and POST15, respectively) of 65-70% of lung units. At POST3, lobar air volume increased 83-148% and tissue (including microvascular blood) volume 120-234% above PRE values without further changes at POST15. Lobar-specific compliance (Cs) increased 52-137% from PRE to POST3 and 28-79% from POST3 to POST15. Inflationrelated parenchyma strain and shear were estimated by detailed registration of corresponding anatomical features at each Ptp. Within each lobe, regional displacement was most pronounced at the caudal region, whereas strain was pronounced in the periphery. Regional three-dimensional strain magnitudes increased heterogeneously from PRE to POST3, with further medial-lateral increases from POST3 to POST15. Lobar principal strains (PSs) were unchanged or modestly elevated postresection; changes in lobar maximum PS correlated inversely with changes in lobar air and tissue volumes. Lobar shear distortion increased in coronal and transverse planes at POST3 without further changes thereafter. These results establish a novel use of functional HRCT to map heterogeneous regional deformation during compensatory lung growth and illustrate a stimulus-response feedback loop whereby postresection mechanical stress initiates differential lobar regrowth and sustained remodeling, which in turn, relieves parenchyma stress and strain, resulting in progressive increases in lobar Cs and a delayed increase in whole lung Cs.

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