Progressive ankylosis in mice

M. L. Mahowald, H. Krug, J. Taurog

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

To determine its similarity to human spondylarthropathies, we studied murine progressive ankylosis, a spontaneously occurring disorder of joints in mice. Clinically, peripheral joints were inflamed initially, then became ankylosed in a predictable sequence from distal to proximal. Forefeet were involved before hindfeet. Axial joint involvement produced severe spinal ankylosis. Extraarticular manifestations included balanitis and crusting skin lesions. Radiographically, bony erosions and calcification of articular and periarticular tissues were extensive, and vertebral syndesmophytes produced a “bamboo” spine. We conclude that progressive ankylosis is a systemic disease with many clinical and radiographic similarities to human spondylarthropathies, and it may represent a useful animal model for the study of the human diseases.

Original languageEnglish (US)
Pages (from-to)1390-1399
Number of pages10
JournalArthritis & Rheumatism
Volume31
Issue number11
DOIs
StatePublished - Nov 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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