Progressive ankylosis in mice. An animal model of spondylarthropathy. I. Clinical and radiographic findings

M. L. Mahowald, H. Krug, J. Taurog

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31 Citations (Scopus)

Abstract

To determine its similarity to human spondylarthropathies, we studied murine progressive ankylosis, a spontaneously occurring disorder of joints in mice. Clinically, peripheral joints were inflamed initially, then became ankylosed in a predictable sequence from distal to proximal. Forefeet were involved before hindfeet. Axial joint involvement produced severe spinal ankylosis. Extraarticular manifestations included balanitis and crusting skin lesions. Radiographically, bony erosions and calcification of articular and periarticular tissues were extensive, and vertebral syndesmophytes produced a 'bamboo' spine. We conclude that progressive ankylosis is a systemic disease with many clinical and radiographic similarities to human spondylarthropathies, and it may represent a useful animal model for the study of the human diseases.

Original languageEnglish (US)
Pages (from-to)1390-1399
Number of pages10
JournalArthritis and Rheumatism
Volume31
Issue number11
StatePublished - 1988

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Spondylarthropathies
Ankylosis
Animal Models
Joints
Balanitis
Spine
Skin

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Progressive ankylosis in mice. An animal model of spondylarthropathy. I. Clinical and radiographic findings. / Mahowald, M. L.; Krug, H.; Taurog, J.

In: Arthritis and Rheumatism, Vol. 31, No. 11, 1988, p. 1390-1399.

Research output: Contribution to journalArticle

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