TY - JOUR
T1 - Progressive cellular immune impairment leading to development of AIDS
T2 - Two-year prospective study of HIV infection in drug addicts
AU - Fernandez-Cruz, E.
AU - Fernandez, A. M.
AU - Gutierrez, C.
AU - Garcia-Montes, M.
AU - De la Morena, M. T.
AU - Rodriguez-Villanueva, J.
AU - Longo, N.
AU - Zabay, J. M.
PY - 1988
Y1 - 1988
N2 - We have studied immunological, serological and clinical abnormalities in 264 HIV-positive and HIV-negative drug abusers. Ninety percent of the 264 drug addicts (mean age 26 ± 0.8 years) were found to have HIV antibodies and there was a significant increase (P < 0.01) in the frequency of HIV antibody positivity with increasing duration of exposure to parenteral drug abuse. There was a very strong correlation between the progressive decline of the mean T4+ helper/inducer cells and T4+/T8+ ratio, the low response to pokeweed mitogen and the more severe clinical manifestations of HIV infection. Impairment of delayed-type hypersensitivity to recall antigens was only seen in group IV as defined by the Center for Disease Control. Within group IV, anergy was found to be highly associated (83%) in patients with opportunistic infections. All other HIV-positive addicts from groups II and III, as well as HIV-negative addicts had normal in vivo responses to test antigens. We have also analysed in a prospective follow-up lasting 6-24 months, the evolution of HIV infection in a cohort of 50 HIV-antibody-positive drug addicts. Thirty-two percent showed clinical progression and most of the drug addicts that proceeded to full-blown AIDS developed anergy (82%) prior to clinical deterioration with development of opportunistic infections. We conclude, that in seropositive drug addicts a low absolute count of helper/inducer cells (mean ± s.e. = 243 ± 48 cells/mm3), a low response to pokeweed mitogen and anergy are predictive markers of progression to AIDS.
AB - We have studied immunological, serological and clinical abnormalities in 264 HIV-positive and HIV-negative drug abusers. Ninety percent of the 264 drug addicts (mean age 26 ± 0.8 years) were found to have HIV antibodies and there was a significant increase (P < 0.01) in the frequency of HIV antibody positivity with increasing duration of exposure to parenteral drug abuse. There was a very strong correlation between the progressive decline of the mean T4+ helper/inducer cells and T4+/T8+ ratio, the low response to pokeweed mitogen and the more severe clinical manifestations of HIV infection. Impairment of delayed-type hypersensitivity to recall antigens was only seen in group IV as defined by the Center for Disease Control. Within group IV, anergy was found to be highly associated (83%) in patients with opportunistic infections. All other HIV-positive addicts from groups II and III, as well as HIV-negative addicts had normal in vivo responses to test antigens. We have also analysed in a prospective follow-up lasting 6-24 months, the evolution of HIV infection in a cohort of 50 HIV-antibody-positive drug addicts. Thirty-two percent showed clinical progression and most of the drug addicts that proceeded to full-blown AIDS developed anergy (82%) prior to clinical deterioration with development of opportunistic infections. We conclude, that in seropositive drug addicts a low absolute count of helper/inducer cells (mean ± s.e. = 243 ± 48 cells/mm3), a low response to pokeweed mitogen and anergy are predictive markers of progression to AIDS.
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M3 - Article
C2 - 3261660
AN - SCOPUS:0023878886
SN - 0009-9104
VL - 72
SP - 190
EP - 195
JO - Clinical and Experimental Immunology
JF - Clinical and Experimental Immunology
IS - 2
ER -