Progressive cellular immune impairment leading to development of AIDS: Two-year prospective study of HIV infection in drug addicts

E. Fernandez-Cruz, A. M. Fernandez, C. Gutierrez, M. Garcia-Montes, M. T. De la Morena, J. Rodriguez-Villanueva, N. Longo, J. M. Zabay

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Abstract

We have studied immunological, serological and clinical abnormalities in 264 HIV-positive and HIV-negative drug abusers. Ninety percent of the 264 drug addicts (mean age 26 ± 0.8 years) were found to have HIV antibodies and there was a significant increase (P < 0.01) in the frequency of HIV antibody positivity with increasing duration of exposure to parenteral drug abuse. There was a very strong correlation between the progressive decline of the mean T4+ helper/inducer cells and T4+/T8+ ratio, the low response to pokeweed mitogen and the more severe clinical manifestations of HIV infection. Impairment of delayed-type hypersensitivity to recall antigens was only seen in group IV as defined by the Center for Disease Control. Within group IV, anergy was found to be highly associated (83%) in patients with opportunistic infections. All other HIV-positive addicts from groups II and III, as well as HIV-negative addicts had normal in vivo responses to test antigens. We have also analysed in a prospective follow-up lasting 6-24 months, the evolution of HIV infection in a cohort of 50 HIV-antibody-positive drug addicts. Thirty-two percent showed clinical progression and most of the drug addicts that proceeded to full-blown AIDS developed anergy (82%) prior to clinical deterioration with development of opportunistic infections. We conclude, that in seropositive drug addicts a low absolute count of helper/inducer cells (mean ± s.e. = 243 ± 48 cells/mm3), a low response to pokeweed mitogen and anergy are predictive markers of progression to AIDS.

Original languageEnglish (US)
Pages (from-to)190-195
Number of pages6
JournalClinical and Experimental Immunology
Volume72
Issue number2
StatePublished - 1988

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Drug Users
HIV Infections
Helper-Inducer T-Lymphocytes
Acquired Immunodeficiency Syndrome
Prospective Studies
HIV
Pokeweed Mitogens
HIV Antibodies
Opportunistic Infections
Intravenous Substance Abuse
HIV Seropositivity
Antigens
CD4-CD8 Ratio
Delayed Hypersensitivity
Centers for Disease Control and Prevention (U.S.)

ASJC Scopus subject areas

  • Immunology

Cite this

Fernandez-Cruz, E., Fernandez, A. M., Gutierrez, C., Garcia-Montes, M., De la Morena, M. T., Rodriguez-Villanueva, J., ... Zabay, J. M. (1988). Progressive cellular immune impairment leading to development of AIDS: Two-year prospective study of HIV infection in drug addicts. Clinical and Experimental Immunology, 72(2), 190-195.

Progressive cellular immune impairment leading to development of AIDS : Two-year prospective study of HIV infection in drug addicts. / Fernandez-Cruz, E.; Fernandez, A. M.; Gutierrez, C.; Garcia-Montes, M.; De la Morena, M. T.; Rodriguez-Villanueva, J.; Longo, N.; Zabay, J. M.

In: Clinical and Experimental Immunology, Vol. 72, No. 2, 1988, p. 190-195.

Research output: Contribution to journalArticle

Fernandez-Cruz, E, Fernandez, AM, Gutierrez, C, Garcia-Montes, M, De la Morena, MT, Rodriguez-Villanueva, J, Longo, N & Zabay, JM 1988, 'Progressive cellular immune impairment leading to development of AIDS: Two-year prospective study of HIV infection in drug addicts', Clinical and Experimental Immunology, vol. 72, no. 2, pp. 190-195.
Fernandez-Cruz E, Fernandez AM, Gutierrez C, Garcia-Montes M, De la Morena MT, Rodriguez-Villanueva J et al. Progressive cellular immune impairment leading to development of AIDS: Two-year prospective study of HIV infection in drug addicts. Clinical and Experimental Immunology. 1988;72(2):190-195.
Fernandez-Cruz, E. ; Fernandez, A. M. ; Gutierrez, C. ; Garcia-Montes, M. ; De la Morena, M. T. ; Rodriguez-Villanueva, J. ; Longo, N. ; Zabay, J. M. / Progressive cellular immune impairment leading to development of AIDS : Two-year prospective study of HIV infection in drug addicts. In: Clinical and Experimental Immunology. 1988 ; Vol. 72, No. 2. pp. 190-195.
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