Progressive multifocal leukoencephalopathy in a renal transplant recipient. Increased diagnostic sensitivity of computed tomographic scanning by double-dose contrast with delayed films

Craig R. Saxton, Peter Gailiunas, J. Harold Helderman, Robert A. Farkas, Rosemary McCoy, Jan Diehl, Arthur I Sagalowsky, F. Kevin Murphy, Elliot D. Ross, Fred R. Silva, Duard L. Walker

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A progressive, deteriorating neurologic disorder developed in a 28-year-old white man 10 years after he successfully received a living related donor kidney transplant. An extensive neurologic evaluation was unrevealing, including normal results of computed tomographic scanning of the brain with and without contrast medium. Repeated computed tomographic scanning after a double dose of radiocontrast medium in conjunction with delayed imaging revealed multiple areas of abnormal enhancement. This technique helped to direct brain biopsy, which led to the early diagnosis of progressive multifocal leukoencephalopathy and the institution of specific therapy.

Original languageEnglish (US)
Pages (from-to)333-337
Number of pages5
JournalThe American journal of medicine
Volume77
Issue number2
DOIs
StatePublished - 1984

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Progressive Multifocal Leukoencephalopathy
Contrast Media
Kidney
Living Donors
Brain
Nervous System Diseases
Nervous System
Early Diagnosis
Transplants
Biopsy
Transplant Recipients
Therapeutics

ASJC Scopus subject areas

  • Nursing(all)

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Progressive multifocal leukoencephalopathy in a renal transplant recipient. Increased diagnostic sensitivity of computed tomographic scanning by double-dose contrast with delayed films. / Saxton, Craig R.; Gailiunas, Peter; Helderman, J. Harold; Farkas, Robert A.; McCoy, Rosemary; Diehl, Jan; Sagalowsky, Arthur I; Murphy, F. Kevin; Ross, Elliot D.; Silva, Fred R.; Walker, Duard L.

In: The American journal of medicine, Vol. 77, No. 2, 1984, p. 333-337.

Research output: Contribution to journalArticle

Saxton, Craig R. ; Gailiunas, Peter ; Helderman, J. Harold ; Farkas, Robert A. ; McCoy, Rosemary ; Diehl, Jan ; Sagalowsky, Arthur I ; Murphy, F. Kevin ; Ross, Elliot D. ; Silva, Fred R. ; Walker, Duard L. / Progressive multifocal leukoencephalopathy in a renal transplant recipient. Increased diagnostic sensitivity of computed tomographic scanning by double-dose contrast with delayed films. In: The American journal of medicine. 1984 ; Vol. 77, No. 2. pp. 333-337.
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