Progressive multifocal leukoencephalopathy in a renal transplant recipient. Increased diagnostic sensitivity of computed tomographic scanning by double-dose contrast with delayed films

Craig R. Saxton, Peter Gailiunas, J. Harold Helderman, Robert A. Farkas, Rosemary McCoy, Jan Diehl, Arthur I Sagalowsky, F. Kevin Murphy, Elliot D. Ross, Fred R. Silva, Duard L. Walker

Research output: Contribution to journalArticle

16 Scopus citations


A progressive, deteriorating neurologic disorder developed in a 28-year-old white man 10 years after he successfully received a living related donor kidney transplant. An extensive neurologic evaluation was unrevealing, including normal results of computed tomographic scanning of the brain with and without contrast medium. Repeated computed tomographic scanning after a double dose of radiocontrast medium in conjunction with delayed imaging revealed multiple areas of abnormal enhancement. This technique helped to direct brain biopsy, which led to the early diagnosis of progressive multifocal leukoencephalopathy and the institution of specific therapy.

Original languageEnglish (US)
Pages (from-to)333-337
Number of pages5
JournalThe American Journal of Medicine
Issue number2
StatePublished - Aug 1984


ASJC Scopus subject areas

  • Medicine(all)

Cite this