Progressive multifocal leukoencephalopathy in pediatric patients: Case report and literature review

Hayden Schwenk, Lynn Ramirez-Avila, Shu Hsien Sheu, Christian Wuthrich, Jeff Waugh, Adam Was, Umberto Degirolami, Sandra Burchett, Igor J. Koralnik, Asim Ahmed

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Progressive multifocal leukoencephalopathy is a rare, demyelinating disease of the central nervous system caused by JC virus. Fewer than 30 cases have been reported in HIV- and non-infected children. We report the case of a 15-year-old girl with progressive multifocal leukoencephalopathy and AIDS who presented with nystagmus, dysarthria and ataxia. Following combined antiretroviral therapy, she developed immune reconstitution inflammatory syndrome, which proved fatal.

Original languageEnglish (US)
Pages (from-to)e99-e105
JournalPediatric Infectious Disease Journal
Volume33
Issue number4
DOIs
StatePublished - Apr 1 2014

Keywords

  • Granule cell neuron
  • HIV
  • JC virus
  • Pediatric
  • Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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    Schwenk, H., Ramirez-Avila, L., Sheu, S. H., Wuthrich, C., Waugh, J., Was, A., Degirolami, U., Burchett, S., Koralnik, I. J., & Ahmed, A. (2014). Progressive multifocal leukoencephalopathy in pediatric patients: Case report and literature review. Pediatric Infectious Disease Journal, 33(4), e99-e105. https://doi.org/10.1097/INF.0000000000000237